Hydroxychloroquine and Chloroquine Retinopathy

This book covers the clinical management of ocular toxicity of hydroxychloroquine and chloroquine for the practicing ophthalmologist, rheumatologist and dermatologist. It also details practice management considerations as well as medico-legal responsibilities.

Malpractice settlements are large for undetected hydroxychloroquine and chloroquine toxicity which, if untreated, can lead to permanent loss of central vision. Knowledge of the ocular toxicity of these drugs has increased during the past fifty years as their use has expanded. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Additionally, the book addresses practice management considerations, including coding, reimbursement and equipment costs, and the medico-legal responsibilities of the rheumatologist and of the ophthalmologist. Guidelines for the management of hydroxychloroquine and chloroquine vary around the world and differences between the guidelines of the United Kingdom, the United States, and other countries are identified. The book concludes with a collection of case examples illustrating common clinical scenarios and their management. This book is a must-have resource for physicians who use these drugs.

First dedicated text on clinical management of ocular toxicity of hydroxychloroquine and chloroquine Written for the practicing ophthalmologist, rheumatologist, dermatologist, and internist Different treatment guidelines from around the world presented Covers fundamentals, including pharmacology, toxicology, toxicity screening and evolution of the drugs' use Lays out important financial and medico-legal considerations, including coding and reimbursement and the clinician's legal responsibility Includes supplementary material: sn.pub/extras

Autorentext
David J. Browning, MD, PhD is an ophthalmologist with a PhD in pharmacology and is on the editorial board of the American Journal of Ophthalmology. He has published two books with Springer, Diabetic Retinopathy and Retinal Vein Occlusions.

Inhalt

1. Preclinical Foundations: Relevant Anatomy and Physiology.- 2. Pharmacology of Chloroquine and Hydroxychloroquine.- 3. Toxicology of Hydroxychloroquine and Chloroquine and the Pathology of the Retinopathy They Cause.- 4. Definitions of Hydroxychloroquine and Chloroquine Retinopathy.- 5. Epidemiology of Hydroxychloroquine and Chloroquine Retinopathy.- 6. Natural History of Hydroxychloroquine and Chloroquine Retinopathy.- 7. Risk Factors for Hydroxychloroquine and Chloroquine Retinopathy.- 8. Ancillary Testing in Screening for Hydroxychloroquine and Chloroquine Retinopathy.- 9. Screening for Hydroxychloroquine and Chloroquine Retinopathy.- 10. Clinical Examples in Managing Patients Taking 4-Aminoquinolines.