Hydroxyl radical in augmented responses to Angiotensin II in SHR rats

Hypertension is a major risk factor for myocardial infarction, heart failure, stroke, peripheral arterial disease and chronic renal failure. It is often associated with metabolic abnormalities such as diabetes and dyslipidemia. Recently it has been hypothesized that oxidative stress is a key player in the pathogenesis of hypertension. Oxidative stress is implicated in the pathophysiology of endothelial damage or dysfunction leading to hypertension. Previous reports shows that hydroxyl radical is involved in the augmented responses to Ang II in diabetic rats. This prompted us to speculate the role of hydroxyl radical in the vascular dysfunction of hypertension in SHR rats.

Autorentext

Dr. Aaishwarya B. Deshmukh tem uma experiência de mais de 11 anos em I&D farmacêutica e académica. Foi cientista executiva no Centro de Investigação Torrent, coordenadora de projectos na Dishman Pharmaceuticals Ltd, Ahmedabad. Tem 20 publicações de investigação, 5 capítulos de livros e já participou em 18 conferências nacionais e internacionais.