Hypoxia-Selective Copper Radiopharmaceuticals

Solid tumours differ from normal tissue in a number
of important ways. Rapid growth and metabolism of
tumours often leads to altered physiology including
changes in vasculature and perfusion which can in
turn induce fluctuations in the supply of nutrients
such as oxygen. Reduced tissue oxygenation, known as
hypoxia, has been linked to radio- and
chemotherapeutic resistance and is often associated
with a poor prognosis for disease-free survival in
cancer patients.

Identification of tumour hypoxia by using
non-invasive imaging techniques such as positron
emission tomography (PET) is vital for clinicians to
provide effective treatment. However, physiological
imaging modalities such as PET require the design and
administration of radioactive imaging agents which
specifically target tumours.

This book provides a background to the basic chemical
concepts and methods used in the rational design of
tumour-selective radiopharmaceuticals with particular
emphasis on the mechanisms by which
copper-based imaging agents target tumour hypoxia.

Autorentext

Jason P. Holland, D.Phil MChem MRSC read Chemistry at theUniversity of York before completing a doctorate at theUniversity of Oxford, Merton College in 2008. He is currently aResearch Fellow at the Memorial Sloan-Kettering Cancer Center,New York.

Klappentext

Solid tumours differ from normal tissue in a numberof important ways. Rapid growth and metabolism oftumours often leads to altered physiology includingchanges in vasculature and perfusion which can inturn induce fluctuations in the supply of nutrientssuch as oxygen. Reduced tissue oxygenation, known ashypoxia, has been linked to radio- andchemotherapeutic resistance and is often associatedwith a poor prognosis for disease-free survival incancer patients. Identification of tumour hypoxia by usingnon-invasive imaging techniques such as positronemission tomography (PET) is vital for clinicians toprovide effective treatment. However, physiologicalimaging modalities such as PET require the design andadministration of radioactive imaging agents whichspecifically target tumours. This book provides a background to the basic chemicalconcepts and methods used in the rational design oftumour-selective radiopharmaceuticals with particularemphasis on the mechanisms by whichcopper-based imaging agents target tumour hypoxia.