I B

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Details

Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. I B (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF- B transcription factor. I B inhibits NF- B by masking the nuclear localization signals (NLS) of NF- B proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, I B blocks the ability of NF- B transcription factors to bind to DNA, which is required for NF- B''s proper functioning. The gene encoding the I B protein is mutated in some Hodgkin''s lymphoma cells; such mutations inactivate the I B protein, thus causing NF- B to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells.

Weitere Informationen

  • Allgemeine Informationen
    • GTIN 09786131269257
    • Editor Lambert M. Surhone, Mariam T. Tennoe, Susan F. Henssonow
    • Genre Physik & Astronomie
    • Größe H220mm x B220mm
    • EAN 9786131269257
    • Format Fachbuch
    • Titel I B
    • Herausgeber Betascript Publishing
    • Anzahl Seiten 104

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