Immunohistochemical evaluation of VEGF-C and COX-2 in PTC

Thyroid cancer is the most common malignant neoplasm of the endocrine system. Although it is a relatively rare pathology, accounting for approximately 1% of new cases of malignant diseases, a trend toward increased incidence has been recognized in various parts of the world. This study analyzed the expression of COX-2 and VEGF-C in patients diagnosed with papillary thyroid carcinoma (PTC) in Goiânia, as well as the possible associations between the expression of these markers and the following factors: lymph node metastasis, distant metastasis, tumor size, age, extravasation/invasion of adjacent tissues, and gender. A total of 165 patients with a confirmed histopathological diagnosis of PTC were evaluated. The results of this study corroborate other studies that have demonstrated the usefulness of COX-2 and VEGF-C proteins in identifying PTC patients at higher risk of disease progression due to their association with the presence of regional lymph node metastases and invasion of adjacent tissue.

Autorentext
Janaina Steger has a degree in Nursing and Obstetrics from the Pontifical Catholic University of Goiás. She is also a specialist in Education and Health from the Oswaldo Cruz Foundation/RJ and has a master's degree in Genetics from PUC-GO. She has experience in the field of Nursing, with an emphasis on Women's Health Nursing and Oncology.