Immunology and Immunopathogenesis of Malaria

Malaria is still a major killer, taking more than 1 million people yearly. The burden falls heavily on Sub-Saharan Africa, where over 90% of malaria deaths are thought to occur. The toll is rising; malaria-specific mortality in young African children may have doubled during the last twenty years, perhaps due to drug resistance, insecticide resistant mosquitoes, poverty, political upheaval, and lack of effective vaccines. Almost all of these deaths are caused by one species of malaria parasites. This book addresses vital issues of malarial immunity and immunopathology, and will interest not only malariologists, but the broader immunological community.

Addresses vital questions of immunopathology surrounding malaria, which kills more than 1 million people annually Discusses drug resistance of the parasite, insecticide resistance of the mosquito, and the effects of poverty and social and political upheaval Includes useful insight and feedback from immunologists working in other infectious diseases Will be of interest to malariologists, and also to the broader immunological community Includes supplementary material: sn.pub/extras

Inhalt
The Dissection of CD8 T Cells During Liver-Stage Infection.- Early Interactions Between Blood-Stage Plasmodium Parasites and the Immune System.- Longevity of the Immune Response and Memory to Blood-Stage Malaria Infection.- ExperimentalModels of Cerebral Malaria.- Glycosylphosphatidylinositols in Malaria Pathogenesis and Immunity: Potential for Therapeutic Inhibition and Vaccination.- The Immunology and Pathogenesis of Malaria During Pregnancy.