Important tools don't forget in acute cardiotoxicity management

This study showed that:- The majority of the studied patients (94%) survived and (6%) of the patients died. - ECG test sensitivity was 100%, specificity was 46.8%, PPV of ECG was 10.7% and NPV was 100%.- MAS score, GCS score, and serum cTnI were very highly significantly increased with death hence could be used as predictors for the mortality.- Serum CK-MB couldn't be used as an outcome predictor.- Serum cTnI>1.0ng/ml had sensitivity 100% and specificity 89.4% and NPV 100% with excellent diagnostic characteristic (accuracy rate 96.4%).- GCS at cut off 10 had corresponding sensitivity 100% and specificity 74.5% and NPV 100% with excellent diagnostic characteristic (accuracy rate 90.8%). - Performing an ECG for every patient with acute poisoning help in early recognizing the possible cardio-toxicity by simple and non-invasive tool.- The protocol of management will be the same in acute toxicity by cardiac drugs and non-cardiac toxins.

Autorentext

Dr/ Meray Medhat Shokry ZagharyLecturer of forensic and clinical toxicology in Faculty of Medicine, Sohag University, Sohag, EgyptDoctorate degree MD in clinical toxicologyMember of American Academy of clinical toxicology (AACT).

Klappentext

This study showed that: The majority of the studied patients (94%) survived and (6%) of the patients died. ECG test sensitivity was 100%, specificity was 46.8%, PPV of ECG was 10.7% and NPV was 100%. MAS score, GCS score, and serum cTnI were very highly significantly increased with death hence could be used as predictors for the mortality. Serum CK-MB couldn t be used as an outcome predictor. Serum cTnI>1.0ng/ml had sensitivity 100% and specificity 89.4% and NPV 100% with excellent diagnostic characteristic (accuracy rate 96.4%). GCS at cut off 10 had corresponding sensitivity 100% and specificity 74.5% and NPV 100% with excellent diagnostic characteristic (accuracy rate 90.8%). Performing an ECG for every patient with acute poisoning help in early recognizing the possible cardio-toxicity by simple and non-invasive tool. The protocol of management will be the same in acute toxicity by cardiac drugs and non-cardiac toxins.