Impurity Profiling of a New Drug Entity

Impurity profiling and drug degradation pathways are essentials features for regulatory acceptance of any new drug entity. Despite of technological advancements in pharmaceutical analysis, structural elucidation of drug molecules, impurities produced during formulation remains challenging tasks for researchers. Unique chemical behavior, complex properties and interactions of different functional groups involved in active pharmaceutical ingredients along with different chemical environments with excipients and storage condition further complicate the issues. Furthermore isolation and characterization of impurities with special references to toxic metabolites is essential for acceptance of new drug molecules by regulatory agencies. Recently discovered and patented nitrate esters of paracetamol having improved analgesic and anti-inflammatory activities then parent drug and less hepatotoxicity in overdose is selected as model drug entity. This book is an attempt to provide experimental insights into the chemical, analytical and establishment of drug degradation pathways in forced conditions in lucid manner for easy understanding to meet future expectations of scientific fraternities.

Autorentext
Dr. Neeraj Mishra is currently working as associate professor in ISF College of Pharmacy, Moga, Punjab, India. With 1 patent and over 40 publications of International and National repute, he is an active researcher in Pharmaceutical Sciences. He has supervised 20 M Pharm and B Pharm students.He was also awarded by ICMR- SRF for his Ph.D. work