iMQC Studies of the Structured Biological Samples

Intermolecular Multiple Quantum Coherence (iMQC)
phenomenon is a new contrast mechanism for the high
resolution NMR/MRI. iMQC signal directly correlates
with the degree 3D magnetization profile created by
the CRAZED pulse sequence is spatially averaged over
the targeted distance scale. In this book, after the
short introduction, numerical simulation of the iMQC
experiment is given. That includes relaxation
processes, instantaneous radio frequency pulses and
gradients as well as original phase cycling, phantom
positioning and rotation techniques. For the rat
sciatic nerve iMQC signal is studied as a function of
sample orientation as well as correlation gradients
direction and strength and later compared
to the data from uniform water sample. The fixed
mouse fibrotic liver samples are then studied under
different orientations of the CRAZED gradients. All
results are verified by numerical simulations.The new
experimental data and its analysis may be of
interest for students and professional scientists
working in MRI and MR spectroscopy of biological samples.

Autorentext

Arman S. Kussainov, Cand.Sci.(Engineering), PhD (Physics):Graduated from Kazakh State National University, Almaty,Kazakhstan and Vanderbilt University, Nashville, TN, USA.

Klappentext

Intermolecular Multiple Quantum Coherence (iMQC)phenomenon is a new contrast mechanism for the highresolution NMR/MRI. iMQC signal directly correlateswith the degree 3D magnetization profile created bythe CRAZED pulse sequence is spatially averaged overthe targeted distance scale. In this book, after theshort introduction, numerical simulation of the iMQCexperiment is given. That includes relaxationprocesses, instantaneous radio frequency pulses andgradients as well as original phase cycling, phantompositioning and rotation techniques. For the ratsciatic nerve iMQC signal is studied as a function ofsample orientation as well as correlation gradientsdirection and strength and later comparedto the data from uniform water sample. The fixedmouse fibrotic liver samples are then studied underdifferent orientations of the CRAZED gradients. Allresults are verified by numerical simulations.The newexperimental data and its analysis may be ofinterest for students and professional scientistsworking in MRI and MR spectroscopy of biological samples.