In Situ Tissue Regeneration

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body's ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body's own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications.

Autorentext
Dr. Lee has extensive knowledge and experience in biomaterials science, especially, biodegradable polymers and tunable hydrogels, with specific training and expertise in key research areas for tissue engineering and regenerative medicine. His research team has developed various biomaterial systems that improve cellular interactions by providing appropriate environmental cues. Dr. Lee's research team also demonstrated the principle of in situ tissue regeneration” that is to take advantage of the body's own regenerating capacity by using the host's ability to mobilize endogenous stem cells to the site of injury. Currently, his research has focused on development of strategies for in situ tissue regeneration in terms of mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system from the perspective of regenerative medicine and tissue engineering. Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering.

Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute's Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.Professor, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC

Inhalt

1. Fundamentals of In Situ Tissue Regeneration
   Sang Jin Lee, James J. Yoo and Antony Atala

   2. Stem Cell Homing
      Mariusz Z. Ratajczak and Ahmed A. Ismail

   3. Immunology - Host Responses to Biomaterials
      John D. Jackson

   4. Foreign Body Reaction and Stem Cell Responses
      Ashwin Nair and Liping Tang

   5. Roles of endogenous growth factors and small peptides in in situ tissue regeneration
      Suna Kim, Hyun Sook Hong and Youngsook Son

   6. Small molecules: Controlling cell fate and function
      Baisong Lu and Anthony Atala

   7. Small RNA Delivery for In Situ Tissue Regeneration
      NaJung Kim, James J. Yoo, Anthony Atala, and Sang Jin Lee

   8. Micro and Nano Topographical cues guiding biomaterial host response
      Deepak M. Kalaskar and Feras Alshomer

   9. Mechanobiology and Mechanotherapy in Tissue Engineering
      Rei Ogawa

   10. A biomimetic strategy to design biomaterials for in situ tissue regeneration
       Ji Hyun Kim and Sang Jin Lee

   11. Impact of Matrix Dynamic Properties on Stem Cell Viability
       Marc B. Taraban1, Yuqi Li, Katherine A. Joyner, Joseph P. Stains and Yihua B. Yu

   12. Cell-free Scaffolds for In situ Tissue Regeneration
       Seung Hun Park, Bo Keun Lee, James Yoo, Sang Jin Lee and Moon Suk Kim

   13. In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design
       T. Konrad Rajab and Harald Ott

   14. Synovial Joint: In Situ Regeneration of Osteochondral and Fibrocartilaginous Tissues by Homing of Endogenous Cells
       Solaiman Tarafder and Chang H. Lee

   15. Bioengineered strategies for tendon regeneration
       Ana I. Gonçalves, Márcia T. Rodrigues, Rui L. Reis and Manuela E. Gomes

   16. Volumetric Muscle Repair In Situ
       Lindsey E. Shapiroa, Ji Hyun Kima, In Kap Ko, Sang Jin Lee, James J. Yoo and Anthony Atalaa

   17. Mending The Heart Through In Situ Cardiac Regeneration
       Jeremy Choon Meng Teo, Selwa Mokhtar Boularaoui, Noaf Salah Ali AlWahab and Nicolas Christoforou

   18. Skin Wound Healing - Skin Regeneration with Pharmacological Mobilized Stem Cells
       Zhaoli Sun and George Melville Williams

   19. In situ renal regeneration
       Hung-Jen Wang, Sang Jin Lee, Anthony Atala and James J. Yoo

   20. Regulatory Aspects: regulation aspects of cell-free biomaterial implants
       Nan Zhang, Alexander Baume, Richard Payne, Julie Allickson

   21. Business Perspective - case study: commercialized cell-free cardiovascular implant
       Alexander Sheehy, Byron Lambert and Richard Rapoza