Infectious Disease Informatics

There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the genomics of pathogens with epidemic potential. This volume addresses the growing need for the critical overview of recent developments in microbial genomics and biomedical informatics relevant to the control of infectious diseases. This field is rapidly expanding, and attracts a wide audience of clinicians, public health professionals, biomedical researchers and computer scientists who are fascinated by the complex puzzle of infectious disease. This book takes a multidisciplinary approach with a calculated move away from the traditional health informatics topics of computerized protocols for antibiotic p- scribing and pathology testing. Instead authors invite you to explore the emerging frontiers of bioinformatics-guided pathogen profiling, the system microbiolo- enabled intelligent design of new drugs and vaccines, and new ways of real-time biosurveillance and hospital infection control. Throughout the book, references are made to different products supplied by public sources and commercial vendors, but this is not an endorsement of these products or vendors.

Recent breakthroughs in rapid, high-throughput molecular profiling of pathogenic microorganisms Focus bioinformatics enabled approaches to pathogen detection, investigation and management of infections New methods of analyzing genetic and geographic data of pathogens to reconstruct evolution and identify migration routes where strains spread Fills gap in bioinformatics aspects of infectious diseases and complements bioinformatics texts devoted to the mainstream of human genetics and cancer

Autorentext

Vitali Sintchenko (MBBS, PhD, FRCPA, FACHI) is a clinical microbiologist and informatician with the Sydney Medical School, The University of Sydney, Australia.

Klappentext

In this book, Vitali Sintchenko brings together a collection of state-of-the-art reviews of informatics applications aiming to improve the diagnosis, prevention, treatment and control of infectious diseases. In response to the need for computational biology techniques geared towards clinical medicine, this volume covers the emerging domains of translational bioinformatics, genomics enabled decision support, intelligent design of vaccines and antimicrobial drugs as well as new types of biosurveillance. This book is written by a diverse, international group of experts in the field and provides clinicians, pathologists, biomedical researchers and informaticians with an essential resource that offers also a fascinating glimpse into the future of this dynamic field.

Vitali Sintchenko (MBBS, PhD, FRCPA, FACHI) is a clinical microbiologist and informatician with the Sydney Medical School, The University of Sydney, Australia.

Inhalt
Informatics for Infectious Disease Research and Control.- Bioinformatics of Microbial Sequences.- Mining Databases for Microbial Gene Sequences.- Comparative Genomics of Pathogens.- Systems Microbiology: Gaining Insights in Transcriptional Networks.- HostPathogen Systems Biology.- Text Mining for Discovery of HostPathogen Interactions.- A Network Approach to Understanding Pathogen Population Structure.- Computational Epitope Mapping.- Pangenomic Reverse Vaccinology.- Immunoinformatics: The Next Step in Vaccine Design.- Understanding the Shared Bacterial Genome.- Computational Grammars for Interrogation of Genomes.- In silico Discovery of Chemotherapeutic Agents.- Informatics for Healthcare Epidemiology.- Automated, High-throughput Surveillance Systems for Public Health.- Microbial Genotyping Systems for Infection Control.- Temporal and Spatial Clustering of Bacterial Genotypes.- Infectious Disease Ontology.- Populations, Patients, Germs and Genes: Ethics Of Genomics and Informatics in Communicable Disease Control.