Integrated Microfluidic Systems for DNA Analysis

MEMS (Micro-Electro-Mechanical-Systems) technologies
and micromachining techniques have been increasingly
employed in the integration of microfluidic devices
designed to automate the generation and analysis of
biomedical samples. Miniaturized devices for
electrophoresis separation and sensing mechanisms
have been successfully developed and provide such
benefits as lower sample consumption, higher
resolution, and improved detection speeds. However,
the sample pretreatment process still requires
significant time and effort. Therefore, an emerging
requirement exists to develop integrated
microfluidic systems for sample pretreatment operations such as cell culture monitoring, cell
lysis, DNA extraction, DNA/reagent mixing and DNA
amplification.

Autorentext

Chia-Yen Lee received his Ph.D. degree in Department of Engineering Science from National Cheng Kung University, Taiwan in 2004. He is currently an Associate Professor in the Department of Materials Engineering at National Pingtung University of Science and Technology, Taiwan. His research interests lie on micro-sensors and -actuators.

Klappentext

MEMS (Micro-Electro-Mechanical-Systems) technologies and micromachining techniques have been increasingly employed in the integration of microfluidic devices designed to automate the generation and analysis of biomedical samples. Miniaturized devices for electrophoresis separation and sensing mechanisms have been successfully developed and provide such benefits as lower sample consumption, higher resolution, and improved detection speeds. However, the sample pretreatment process still requires significant time and effort. Therefore, an emerging requirement exists to develop integrated microfluidic systems for sample pretreatment operations such as cell culture monitoring, cell lysis, DNA extraction, DNA/reagent mixing and DNA amplification.