Integrative Human Biochemistry

This book covers in detail the mechanisms for how energy is managed in the human body. The basic principles that elucidate the reactivity and physical interactions of matter are addressed and quantified with simple approaches. Three-dimensional representations of molecules are presented throughout the book so molecules can be viewed as unique entities in their shape and function.

The book is focused on the molecular mechanisms of cellular processes in the context of human physiological situations such as fasting, feeding and physical exercise, in which metabolic regulation is highlighted. Furthermore the book uses key historical experiments that opened up new concepts in biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges.

New to this edition:

• 30 challenging practical case studies (2-3 at the end of each chapter) based on movies, novels, biographies, documentaries, paintings, and other cultural and artistic creations far beyond canonic academic exercises.

• A set of challenging questions and problems in the end of each case study to further engage students with the applications of medical biochemistry

• Insights into the answers to the challenging questions to help steer teaching/learning interactions key to productive lectures, PBL (problem-based learning) or traditional tutorials, or e-learning approaches.

  Advance praise for the second edition:

  The Challenging Cases are compelling both from a scientific viewpoint and for the perspective they provide on the history of medicine . David M. Jameson, University of Hawaii

  Using case studies to reinforce the biochemistry lessons is extremely effective as well as entertaining! Joseph P. Albanesi, UT Southwestern Medical Center

  Advance Praise for the first edition:

  This textbook provides a modern and integrative perspective of human biochemistry and will be a faithful companion to health science students following curricula in which this discipline is addressed. This textbook will be a most useful tool for the teaching community. Joan Guinovart

  Former director of the Institute for Research in Biomedicine, Barcelona, Spain, and former president of the International Union of Biochemistry and Molecular Biology, IUBMB

  Elucidates the foundations of the molecular events of life Uses key historical experiments that opened up new concepts in biochemistry to further illustrate how the human body functions at molecular level, helping students to appreciate how scientific knowledge emerges Includes 30 new case studies drawn from both life and fiction to illustrate the far-ranging applications of human biochemistry Provides realistic representations of molecules and molecular assemblies throughout the book, making structure-function relationships more intuitive and easier to perceive

  Autorentext
  Miguel A.R.B. Castanho, PhD, is Principal Investigator at the Institute of Molecular Medicine and Head of the Biochemistry Department of the School of Medicine of the University of Lisbon, Portugal.

  Andrea T. Da Poian, PhD, is Principal Investigator at the Institute of Medical Biochemistry Leopoldo de Meis of the Federal University of Rio de Janeiro, Brazil.

Inhalt
Part I The molecules of life.- Introduction: Life is made of molecules!.- The chemistry and physics of life.- The families of biological molecules.- Part II The interplay and regulation of metabolism.- Introduction to metabolism.- The regulation of metabolism.- Energy conservation in metabolism: the mechanisms of ATP synthesis.- Catabolism of the major biomolecules.- Metabolic responses to hyperglycemia.- Regulation and integration of metabolism during hypoglycemia.- Regulation and integration of metabolism during physical activity.- Control of body weight and the modern metabolic diseases.- Index.