INTERACTIONS OF FLAVONES AND RELATED COMPOUNDS WITH NUCLEIC ACIDS

Across the world, different diseases have been
treated with herbal extracts, based on common and
empiric knowledge. The process of identification of
the active compounds and their synthesis,
optimisation and development for new drug candidates
appropriate for clinical use is described as
Medicinal Chemistry; a discipline merging chemistry
and pharmacology.
This monograph describes a group of active
ingredients from herbal medicines, as a foundation
for the development of new anticancer drugs.
Interactions between with genomic DNA, synthetic
polynucleotides and higher order DNA isoforms (triple
and quadruple helical forms) have been studied.
Rational drug design has been also employed during
this project to elucidate the mode of binding and
novel compounds have been synthesized to provide
precise structure-activity related studies resulting
in a second generation of chemotherapeutic anticancer
agents with improved properties.
This book provides information and protocols for
studying drug-DNA interactions using spectroscopical
and biological techniques; synthesis of flavonoids
and the principles to explore the use of Quantitative
Structure Activity Relationship Studies.

Autorentext

Chemistry Degree, Universidad del Salvador, Argentina, 1997.
Specialisation in Protein Biochemistry, Institute Leloir,
Argentina, 2001.
PhD in Medicinal Chemistry, Open University, United Kingdom,

2005. Postdoctoral fellowship in Biophysical Studies, Brown
      Cancer Centre, USA, 2008.
      Sr Scientist, ADMETox Lab., Peakdale Mol., United Kingdom, present.

      Klappentext

      Across the world, different diseases have been
      treated with herbal extracts, based on common and
      empiric knowledge. The process of identification of
      the active compounds and their synthesis,
      optimisation and development for new drug candidates
      appropriate for clinical use is described as
      Medicinal Chemistry; a discipline merging chemistry
      and pharmacology.
      This monograph describes a group of active
      ingredients from herbal medicines, as a foundation
      for the development of new anticancer drugs.
      Interactions between with genomic DNA, synthetic
      polynucleotides and higher order DNA isoforms (triple
      and quadruple helical forms) have been studied.
      Rational drug design has been also employed during
      this project to elucidate the mode of binding and
      novel compounds have been synthesized to provide
      precise structure-activity related studies resulting
      in a second generation of chemotherapeutic anticancer
      agents with improved properties.
      This book provides information and protocols for
      studying drug-DNA interactions using spectroscopical
      and biological techniques; synthesis of flavonoids
      and the principles to explore the use of Quantitative
      Structure Activity Relationship Studies.