Interleukin-10

The presented information reflects a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and will contribute to our understanding of the role of ILj-10 in the immune system and its potential clinicial utility in the near future. The book contains chapters in which the in vitro biological effects of IL-10 on both mouse and human lymphoid and myeloid cells are reviewed. In addition, the role of IL-10 in transplantation, parasite infections, inflammation, infectious diseases and bone formation is described. The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice.

Inhalt

1. Molecular Biology of Interleukin-10 and its Receptor.- 2. Physicochemical and Structural Properties of Interleukin-10.- 3. IL-10 and Human T Cells.- 4. Interleukin-10 and B Lymphocytes.- 5. Regulation of Human Monocyte Functions by Interleukin-10.- 6. Interleukin-10: An Inhibitor of Macrophage-Dependent Stimulation of Th1 Cells.- 7. IL-10 and Bone Formation/Hematopoiesis.- 8. Regulatory Function of IL-10 in Experimental Parasitic Infections.- 9. IL-10 in Mycobacterial Infection.- 10. IL-10 In Human Leishmaniasis.- 11. IL-10 and HIV-1 Replication.- 12. Interleukin-10 and Transplantation Tolerance.- 13. Effects Of IL-10 in Lipopolysaccharide- and Superantigen-Induced Lethal Shock In Vivo.- 14. Inhibition of Cell-Mediated Immune Responses In Vivo by Recombinant IL-10.- 15. IL-10 Transgenic Mice.- 16. Interleukin-10 Deficient Mice.- 17. A Phase I Study of Interleukin-10 in Healthy Humans: Safety and Effects on Cytokine Production.