Interplay between Metal Ions and Nucleic Acids

Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

Provides an up-to-date information on nucleic acid-metal ion interactions Indicates future developments (nanotechnology) involving DNA and RNA Valuable for teaching courses in Inorganic Biochemistry Describes the analytical tools needed in nucleic acid chemistry Describes comprehensively DNAzymes Describes the technology of DNA

Klappentext

The Metal Ions in Life Sciences series links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry.

MILS-10: Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

The Editors
Astrid Sigel, Helmut Sigel and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. They published on metal ion interactions with nucleotides and nucleic acids and on related topics, and edited previously 44 volumes in the series Metal Ions in Biological Systems*.*

Inhalt

1. Characterization of Metal Ion-Nucleic Acid Interactions in Solution. - 2. Nucleic Acid-Metal Ion Interactions in the Solid State. - 3. Metal Ion-Promoted Conformational Changes of Oligonucleotides. - 4. G-Quadruplexes and Metal Ions. - 5. Metal Ion-Mediated DNA-Protein Interactions. - 6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids. - 7. Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes. - 8. Metal Ion-Dependent DNAzymes and Their Applications as Biosensors. - 9. Enantioselective Catalysis at the DNA Scaffold. - 10. Alternative DNA Base Pairing through Metal Coordination. - 11. Metal-Mediated Base Pairs in Nucleic Acids with Purine- and Pyrimidine-Derived Nucleosides. - 12. Metal Complex Derivatives of Peptide Nucleic Acids.