Intramolecular Cyclopropanation/Thermal Fragmentation strategy

The development of a novel methodology toward the construction of 5-7 ring systems. These ring systems are skeletons of a versatile class of many natural products with diverse biological activities. These structures are accessed starting with the preparation of functionalized cyclobutenes and applying a new intramolecular cyclopropanation/thermal fragmentation strategy. To expand the scope of these reactions to include additional functionality, a tethered diazo moiety has been attached onto the cyclobutene. The substrate is subjected to the transition metal- catalyzed diazo decomposition conditions to afford the desired intramolecular cyclopropanation product. The added functionality provides a handle for further manipulations for the synthesis of natural products with more structural complexity.

Autorentext

Florence studied chemistry at the University of Hartford and organic chemistry as a graduate student at Boston College. Working as a medicinal chemist in UCB Pharma, Boston she devoted her time to synthesizing new leads for asthma therapy and Parkinson's Disease. Currently she is working at Cana Pharma, Athens Greece with an MBA degree.