Iron-Catalysed Hydrofunctionalisation of Alkenes and Alkynes

This thesis gives a thorough account of the development of iron-catalysed hydrosilylation, hydroboration and hydromagnesiation reactions. With extraordinary referencing and scientific argument, Mark Greenhalgh describes the development of methodologies which require only commercially available materials and non-specialised techniques. The intention of this approach is to ensure the science can be adopted widely by the chemical community. In addition to an insight into the processes involved in methodology development, Greenhalgh discusses and determines the relevant reaction mechanisms. This thesis provides not only the most thorough review of the area, but offers a level of insight well beyond that expected from a Ph.D. student. The work in this thesis has been published at the highest level, and the results and ideas have led to 3 industry-funded Ph.D. studentships and grant income in excess of £1 million.

Nominated as an outstanding Ph.D.thesis by the University of Edinburgh Provides a comprehensive review of the area with an extraordinary level of referencing Details both the development of novel chemical reactions and investigation of reaction mechanism Includes supplementary material: sn.pub/extras

Autorentext
Mark studied Chemistry with a year in Australia at the University of Sheffield, graduating in 2010 after completing his final year project with Dr Simon Jones. He joined the Chemical Synthesis DTC at the University of Bristol in 2010, and began his PhD the following year with Dr Steve Thomas and Prof. Paul Pringle on iron-catalysed hydrofunctionalisation of alkenes and alkynes. He moved with Steve to the University of Edinburgh in 2012 to complete his PhD studies. Mark has recently moved to St. Andrews to work with Prof. Andrew Smith on the development of Lewis base-catalysed asymmetric methodologies.

Inhalt
Introduction.- Iron-Catalysed Hydrosilylation of Alkenes and Alkynes.- Iron-Catalysed Hydroboration of Alkenes and Alkynes.- Iron-Catalysed Hydromagnesiation of Styrene Derivatives.- Experimental.- References