Ligand Efficiency Indices for Drug Discovery

Klappentext The purpose of Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of new variables and more objective numerical methods to drive drug discovery in an encompassing way. These new variables are based on LEIs formulated in a way that permits mapping chemico-biological space in an Atlas-like representation. "Abad-Zapatero presents a novel approach to drug discovery that is based on the notion that a change of variables is necessary. The algebraic framework he proposes combines the affinity between ligands and targets with the physico-chemical properties of the ligands to construct a set of novel variables that can map chemico-biological space (CBS) and optimize the drug-discovery process."--Reference and Research Book News, August 2013 Zusammenfassung Emphasizes the use of 'new variables' and objective numerical methods to drive drug discovery in an encompassing way. This book provides a practical discussion of the concepts! ideas! applications and examples of efficiency-driven drug discovery. Inhaltsverzeichnis IntroductionPART 1: The Elements: Data, Variables, Concept and the ServerPART 2: Conceptual Applications of the AtlasCBS: A New ParadigmPART 3: Exploring CBS: Practical Examples Using the AtlasCBS ServerReferencesEpilogueAppendix I. Appendix II.

Zusammenfassung
Emphasizes the use of 'new variables' and objective numerical methods to drive drug discovery in an encompassing way. This book provides a practical discussion of the concepts, ideas, applications and examples of efficiency-driven drug discovery.

Inhalt

IntroductionPART 1: The Elements: Data, Variables, Concept and the ServerPART 2: Conceptual Applications of the AtlasCBS: A New ParadigmPART 3: Exploring CBS: Practical Examples Using the AtlasCBS ServerReferencesEpilogueAppendix I. Appendix II.