Lipid Metabolism in Tumor Immunity

This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery.

Provides an overview of lipid metabolism in tumor immunity Promotes the understanding of lipidomics and its applications Sheds light on both basic and clinical research on tumor immunotherapy, as well as potential drug discovery

Autorentext

Dr. Yongsheng Li now is Professor and Deputy Director of Clinical Medicine Research Center in Xinqiao Hospital, Army Medical University in Chongqing, China. He obtained his M.D. from Yunyang Medical College of Tongji Medical University in 2005 and his Ph.D. from Huazhong University of Science and Technology in 2009, respectively. After that, he was Research Fellow in Beth Israel Deaconess Medical Center. Later, from 2010 to 2015, he continued his post-doctoral training in Brigham and Women s Hospital in the USA as research fellow. In 2016, he moved back to China and joined Army Medical University (A.K.A. Third Military Medical University) and the same year, he was selected in the "Youth 1000 Talent Plan" of China.

Inhalt

1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity.- 2. ipid metabolism and lipidomics.- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment.- 5. Lipid metabolism in cancer cells.- 6. Lipid metabolism in tumour-associated NK.- 7. Lipid metabolism in tumour-associated macrophages.- 8. Lipid metabolism in tumour-associated MDSCs.- 9. Lipid metabolism in tumour-associated fibroblasts.- 10. Lipid metabolism in tumour-associated B cells.- 11. Lipid metabolism in tumour-infiltrating T cells.- 12. Lipid metabolism and angiogenesis.- 13. Lipid metabolism and tumor antigen-presenting.- 14. Lipid metabolism and immune checkpoints.