Long Non-coding RNAs in Human Disease

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Summarizes the tremendous progress made within the last decade in understanding the roles of lncRNA in Bridges the divide between inferring lncRNA mechanisms and targeting lncRNAs by means of rational therapeutics Stresses the vital role of lncRNA disease mechanisms for a necessary and profound reassessment of Genome-Wide Association studies in the new era of personalized medicine Includes supplementary material: sn.pub/extras

Autorentext
Kevin Morris is an Associate Professor at the Department of Molecular and Experimental Medicine, The Scripps Research Institute in La Jolla, CA, USA. The responsible series editor is Peter K. Vogt, The Scripps Research Institute in La Jolla, CA, USA.

Inhalt
Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and its Implications in Disease Conditions.- Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease.- Form and function of exosome associated long non-coding RNAs in cancer.- Long Non-coding RNAs in Lung Cancer.- Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease.- Functional long non-coding RNAs in vascular smooth muscle cells.- Long Non-coding RNAs as Targets and Regulators of Nuclear Hormone Receptors.- Non-coding transcriptional landscape in human aging.- LncRNAs in stress response.- Expression Specificity of Disease-Associated lncRNAs: towards Personalized Medicine.