Macrolide Antibiotics

Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.

Zusammenfassung
Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the

Inhalt

Contributors
Preface

1. Discovery of New Macrolides
   I. Introduction
   II. Macrolides from Actinomycetes
   III. Macrolides from Bacteria Including Myxobacteria
   IV. Macrolides from Fungi
   V. Macrolides from Plants and Lichens
   VI. Macrolides from Insects
   VII. Other Macrolides
   VIII. Concluding Remarks
   References
2. Discovery of New Macrolides from Marine Organisms
   I. Introduction
   II. Macrocyclic Lactones of Marine Organism Origin
   III. Concluding Remarks
   References
3. Chemical Modification of Macrolides
   I. Introduction
   II. Fourteen-Membered Macrolides
   III. Sixteen-Membered Macrolide Antibiotics and the Avermectin Family
   IV. Concluding Remarks
   References
4. Total Synthesis of Macrolides
   I. Introduction
   II. Synthetic Strategy for Macrolide Synthesis
   III. Total Synthesis of Selected Macrolides
   IV. Concluding Remarks
   References
5. Biosynthesis, Regulation, and Genetics of Macrolide Production
   I. Introduction
   II. Reaction Mechanism of Polyketide Biosynthesis
   III. Polyketide Synthase
   IV. Genes Encoding Modular Polyketide Synthase
   V. Sugar Biosynthesis
   VI. Genetic Manipulation of PKS Genes
   References
6. Pharmacokinetics and Metabolism of Macrolides
   I. Introduction
   II. Pharmacokinetics and Metabolism
   III. Drug Interaction
   IV. Concluding Remarks
   References
7. Antimicrobial Macrolides in Clinical Practice
   I. Introduction
   II. Fourteen- and Fifteen-Membered Macrolides
   III. Sixteen-Membered Macrolides
   IV. Concluding Remarks
   References
8. Ivermectin in Clinical Practice
   I. Introduction
   II. Novel Activity of Ivermectin in Clinical Practice
   III. Concluding Remarks
   References
9. Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice
   I. Introduction
   II. Tacrolimus, a Brief Developmental History
   III. Novel Activity of Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice
   IV. Concluding Remarks
   References
10. Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides
    I. Introduction
    II. Mode of Action of Macrolide Antibiotics
    III. Mechanisms of Resistance to Antimicrobial Macrolides
    IV. Important Developments in Macrolide Antibiotics
    V. Concluding Remarks
    VI. Addendum
    References
11. Mode of Action of Macrolides with Motilin Agonistic Activity--Motilides
    I. Introduction
    II. Mode of Action of Motilin
    III. Invention of Motilides
    IV. BiologicalActivity of Motilides
    V. Clinical Trials of Motilides
    VI. Concluding Remarks
    References
12. Novel Activity of Erythromycin and Its Derivatives
    I. Erythromycin Treatment in Diffuse Panbronchiolitis
    II. Inhibition of Chloride Channel
    III. Effects of Macrolides on Cytokine/Chemokine Expression
    IV. Modulation of Bacterial Function
    V. New Challenge for Novel Action
    References
13. Mode of Action of Avermectin
    I. Introduction
    II. Target of Avermectin Action
    III. Cloning and Structure of Avermectin Binding Protein
    IV. Concluding Remarks
    References
14. Mode of Action of FK506 and Rapamycin
    I. Introduction
    II. Initial Cellular Target for FK506 and Rapamycin; Peptidyl Prolylcis-trans Isomerases (Rotamases, Immunophilins)
    III. Target of FK506-FKBP12 Complex: Calcineurin
    IV. Target of Rapamycin-FKBP12 Complex: mTOR/FRAP/RFAT
    V. Intervention of Intracellular Signaling Pathways by FK506 and Rapamycin
    References
    Index