Malaria

Currently, malaria kills more than 300,000 people per year, making it a top priority of world leaders and international organizations, who are working towards implementing and coordinating efforts to eradicate this disease. An effective malaria vaccine is recognized as the key element that will decide between success and failure in this fight. At present, despite intensive research efforts, such a vaccine is not yet available for use. However, there are a number of advanced candidate vaccines with high chances of success in the short term.

Malaria: Immune Response to Infection and Vaccination provides a comprehensive view on the immune response to malaria and to the different vaccines under development. The book offers the following:

• Contributions by top research leaders in the field,

• Comparisons of the immune responses to both malaria infection and malaria vaccines, which are traditionally treated separately,

• Coverage of the immune responses to the different stages of malaria, which are frequently treated as separate fields of research.

  Contributed by top research leaders in the field Compares the immune responses to both malaria infection and malaria vaccines, which are traditionally treated separately Covers the immune responses to the different stages of malaria Includes supplementary material: sn.pub/extras

  Autorentext

Maria M. Mota, Instituto de Medicina Molecular, Lisbon, Portugal

Ana Rodriguez, New York University School of Medicine, Department of Microbiology, New York, USA

Inhalt
Part I. Immune Response to Infection.- Innate Immunity to Malaria.- Mechanisms of Adaptive Immunity to Plasmodium Liver-Stage Infection: The Known and Unknown.- Adaptive Immunity to Blood Stages.- Pathogenetic Immune Responses in Cerebral Malaria.- A Role for Autoimmunity in the Immune Response Against Malaria.- Part II. Immune Response to Malaria Vaccines - Liver Stage Vaccines.- Whole-Sporozoite Malaria Vaccines.- Immune Responses to the RTS,S/AS01 Malaria Vaccine Candidate: Lessons from Human Immunology, Parasitologic and Clinical Evaluations.- Viral Vector Vaccines for Liver Stage Malaria.- Epitopic Malaria Vaccines Comprised of Minimal T and B cell Epitopes of the P. falciparum CS Protein.- Part III. Immune Response to Malaria Vaccines - Blood Stage Vaccines.- Immune Responses to Whole Organism Blood-Stage Malaria Vaccines.- Subunit Vaccines.- Part IV. Immune Response to Malaria Vaccines - Transmission Blocking Vaccines.- Antimalarial Transmission Blocking Vaccines.