Matrix Metalloproteinases

Klappentext The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions. "It is an encyclopedia and up-to-date compendium of the minute details of the literature on all characterized MMPs for specialists in this field... would I buy it? Yes." --CELL "In all, this book is a very comprehensive coverage of the specialized area of MMPs. The editors and contributors describe not only the current status of research being conducted in this field, but also speculate on the future direction of that research." --DOODY'S PUBLISHING REVIEWS Zusammenfassung Covers the structure, regulation, and function of matrix metalloproteinases, and provides information on the strategies to inhibit enzyme activity. This work is intended for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, pathology, and therapeutic interventions. Inhaltsverzeichnis Contributors. Preface. The Matrix Metalloproteinase Family, J.F. Woessner, Jr. . Interstitial Collagenases, J.J. Jeffrey . Stromelysins 1 and 2, H. Nagase . 72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity, A.E. Yu, A.N. Murphy and W.G. Stetler-Stevenson . Gelatinase B: Structure, Regulation, and Function, T.H. Vu and Z. Werb . Matrilysin, C.L. Wilson and L.M. Matrisian . Macrophage Elastase (MMP-12), S.D. Shapiro and R.M. Senior . Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases, V. Knauper and G. Murphy . Substrate Specificity and Mechanism of Substrate Recognition of the Matrix Metalloproteinases, V. Imper and H.E. Van Wart . Synthetic Inhibitors of Matrix Metalloproteinases, P.D. Brown . Matrix Metalloproteinases in Tissue Repair, W.C. Parks, B.D. Sudbeck, G.R. Doyle and U.K. Saariahlo-Kere . Regulation of Matrix Metalloproteinase Gene Expression, M.E. Fini, J.R. Cook, R. Mohan and C.E. Brinckerhoff . Index....

Zusammenfassung
Covers the structure, regulation, and function of matrix metalloproteinases, and provides information on the strategies to inhibit enzyme activity. This work is intended for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, pathology, and therapeutic interventions.

Inhalt

Contributors.
Preface.
The Matrix Metalloproteinase Family, J.F. Woessner, Jr..
Interstitial Collagenases, J.J. Jeffrey.
Stromelysins 1 and 2, H. Nagase.
72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specificity, A.E. Yu, A.N. Murphy and W.G. Stetler-Stevenson.
Gelatinase B: Structure, Regulation, and Function, T.H. Vu and Z. Werb.
Matrilysin, C.L. Wilson and L.M. Matrisian.
Macrophage Elastase (MMP-12), S.D. Shapiro and R.M. Senior.
Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases, V. Knauper and G. Murphy.
Substrate Specificity and Mechanism of Substrate Recognition of the Matrix Metalloproteinases, V. Imper and H.E. Van Wart.
Synthetic Inhibitors of Matrix Metalloproteinases, P.D. Brown.
Matrix Metalloproteinases in Tissue Repair, W.C. Parks, B.D. Sudbeck, G.R. Doyle and U.K. Saariahlo-Kere.
Regulation of Matrix Metalloproteinase Gene Expression, M.E. Fini, J.R. Cook, R. Mohan and C.E. Brinckerhoff.
Index.