Matrix Metalloproteinases and Periodontal Disease

The disease progression involves a network of interacting molecular pathways made of pro-inflammatory mediators like cytokines, growth factors, reactive oxygen species,matrix metalloproteinases (MMPs), and their inhibitors and regulators. Matrix macromolecules like proteoglycan and non- ollagen protein can be degraded by proteinases from the four major classes (metallo, serine, cysteine, and aspartic active site residues). Matrix metalloproteinases (MMPs) are members of a large subfamily of Zn 2+ and Ca 2+ dependent proteolytic enzymes, playinganimportant role in periodontal destruction.

Autorentext

Dr.SRIKUMAR G.P.V,BDS,MDS, Chefe do Departamento de Dentisteria Conservadora e Endodontia do TIDSHRC. Membro da IACDE,ISRP,IDADr. KIRAN.S,BDS,MDS,Professor do Departamento de Dentisteria Conservadora e Endodontia no TIDSHRC. Membro da IACDEO Dr. Shikha Sharma é um estudante de pós-graduação do último ano do TIDSHRC e membro da IACDE.