Mechanisms and Pathways of Heterotrimeric G Protein Signaling

Klappentext This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric G N n nproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins. Zusammenfassung Features articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GfNfnfnproteins. Inhaltsverzeichnis 1. Structural basis of effector regulation and signal termination in heterotrimeric G Ñ n nproteins Stephen R. Sprang, Zhe Chen and Xinlin Du 2. How do receptors activate G proteins? William M. Oldham and Heidi E. Hamm 3. Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads Tione Buranda, Anna Waller, Yang Wu, Peter C. Simons, Sean Biggs, Eric R. Prossnitz and Larry A. Sklar 4. Activation of G protein coupled receptors Xavier Deupi and Brian Kobilka 5. Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells Martin J. Lohse, Carsten Hoffmann, Viacheslav O. Nikolaev, Jean-Pierre Vilardaga and Moritz Bunemann 6. Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins Paul C. Sternweis, Angela M. Carter, Zhe Chen, Shahab M. Danesh, Ying-Fan Hsiung, and William D. Singe

Zusammenfassung
Features articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GfNfnfnproteins.

Inhalt

1. Structural basis of effector regulation and signal termination in heterotrimeric G Ñ n nproteins
   Stephen R. Sprang, Zhe Chen and Xinlin Du

   2. How do receptors activate G proteins?
      William M. Oldham and Heidi E. Hamm

   3. Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads
      Tione Buranda, Anna Waller, Yang Wu, Peter C. Simons, Sean Biggs, Eric R. Prossnitz and Larry A. Sklar

   4. Activation of G protein coupled receptors
      Xavier Deupi and Brian Kobilka

   5. Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells
      Martin J. Lohse, Carsten Hoffmann, Viacheslav O. Nikolaev, Jean-Pierre Vilardaga and Moritz Bunemann

   6. Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins
      Paul C. Sternweis, Angela M. Carter, Zhe Chen, Shahab M. Danesh, Ying-Fan Hsiung, and William D. Singe