Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes

Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks.

Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.

In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications.

The application of fullerenes and nanotubes in medicine is at the frontier of our knowledge, thus the work in this field represents the basis for future novel developments.

The first contributed volume to feature the recent developments which solely involve the pharmacological and biomaterials applications as well as the chemical properties of fullerenes

Klappentext

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes features important insights into the applications of fullerenes and carbon nanotubes. It discusses the fullerene and nanotubes derivatives which are effective against viruses, cells, and bacteria and those which are able to interact and inhibit certain enzymes. Also covered in this book are the formation of complex structures between biologically active molecules and carbon materials. Furthermore, the application of fullerenes in certain medical therapies is explored, including the very recent discovery of new bio-compatible media which could be used as carriers in the delivery of fullerenes in vivo. An additional topic of this text is the formation of hybrids between nanotubes and biological molecules and their use as chemical sensors.

Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes will be a useful tool of reference for researchers, postgraduates and advanced undergraduates in the Chemical, Biomedical, and Materials sciences.

Inhalt
Twenty Years of Promises: Fullerene in Medicinal Chemistry.- Biomedical Applications of Functionalised Carbon Nanotubes.- Antioxidant Properties of Water-Soluble Fullerene Derivatives.- Fullerenes as Photosensitizers in Photodynamic Therapy.- Photodynamic Inactivation of Enveloped Viruses by Fullerene: Study of Efficacy and Safety.- Effects of Photoexcited Fullerene C60-Composites in Normal and Transformed Cells.- Biological Effects in Cell Cultures of Fullerene C60: Dependence on Aggregation State.- Gadolinium Endohedral Metallofullerene-Based MRI Contrast Agents.- Biomolecules Functionalized Carbon Nanotubes and Their Applications.- Applications of Carbon-Based Nanomaterials for Drug Delivery in Oncology.- Visualization of Carbon Nanoparticles Within Cells and Implications for Toxicity.- Pharmacological Applications of Biocompatible Carbon Nanotubes and Their Emerging Toxicology Issues.- Solubility of Fullerenes in Fatty Acids Esters: A New Way to Deliver In Vivo Fullerenes. Theoretical Calculations and Experimental Results.- New Approach to QSPR Modeling of Fullerene C60 Solubility in Organic Solvents: An Application of SMILES-Based Optimal Descriptors.- Functionalized Nanomaterials to Sense Toxins/Pollutant Gases Using Perturbed Microwave Resonant Cavities.- Cellular Nanotubes: Membrane Channels for Intercellular Communication.