Metal Transporters: Volume 69

This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others.

Klappentext

This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others.

Zusammenfassung
Focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. This book summarizes the advances in the field of metal ion transport and provides a overview of the major classes of transporters involved in homeostasis of heavy metals.

Inhalt

1. Metal ion physiology: Mechanistic approach
   Svetlana Lutsenko
   
   2. Transferrin mediated iron uptake
      Anne B. Mason
   3. Structure-function of siderophore-iron transporters
      Isabelle J. Schalk
   4. Iron transport machinery of human cells: players and their interactions
      Caroline A. Enns
   5. Mechanism of copper uptake in mammalian cells
      Vinzenz Unger and Jack H. Kaplan
      6. Heavy metal transport P-type ATPases
      Amy C. Rosenzweig and Jose Argüello
   6. CUS periplasmic Cu+ efflux system
      Ninian J. Blackburn and Megan McEvoy
   7. Molecular architecture and function of ZnT transporters
      Taiho Kambe
   8. Structure-function of ZIP transporters
      Robert E. Dempski
   9. Nramp family of transporters
      Mathieu F. Cellier
   10. Plant YSL metal transporters
       Elsbeth Walker and Sarah S. Conte
   11. Pathways of arsenic uptake and detoxification
       Barry P. Rosen
   12. Mechanisms of heme transport and trafficking
       Angela Wilks
   13. Mechanisms of Mg2+ and Co2+ transport
       Said Eshaghi