Metals and Oxidative Damage in Neurological Disorders

The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. Indeed the goal of this book is to show that the investiga tive approaches and potential therapeutic interventions perhaps do not vary as widely as some may think. I think that the readers of this book will not read it from front to back, but will pick chapters of interest. Thus, the chapters are organized to contain information that is essential to understanding basic aspects of oxidative injury, and thus have some redundancy. However, within the context of each chapter the reader should hopefully find impetus and direction to go on to another chapter. The book is divided into three seetions. The first section contains reviews of metals and their role in generating oxidative injury. lron is considered in three of these chapters because of its relative abundance in the brain and its potency in inducing free radicals. The second section focuses on mechanisms by which the brain attempts to protect itself from oxidative injury. Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate gies in neurological disorders.

Klappentext

This volume brings together scientists and clinicians from diverse disciplines for discussions of oxidative injury in the nervous system. Areas of examination include:ul li a review of metals and their role in oxidative injury, with special attention paid to iron /li li the mechanisms by which the brain protects itself from oxidative harm /li li the clinical diseases in which oxidative injury is known to contribute to the pathogenic process /li li antioxidant therapeutic strategies in neurological disorders, and /li li a proposed common pathway for oxidative injury in the brain./li /ul

Inhalt
1 Iron and Neurotransmitter Function in the Brain.- 2 Evidence for Iron Mismanagement in the Brain in Neurological Disorders.- 3 Magnetic Resonance Imaging of Brain Iron.- 4 Neurochemical Roles of Copper as Antioxidant or Prooxidant.- 5 Manganese Neurotoxicity and Oxidative Damage.- 6 The Role of Zinc in Brain and Nerve Functions.- 7 Delivery of Metals to Brain and the Role of the Blood-Brain Barrier.- 8 Ferritin: Intracellular Regulator of Metal Availability.- 9 Ascorbate: An Antioxidant Neuroprotectant and Extracellular Neuromodulator.- 10 Vitamin E: Neurochemical Aspects and Relevance to Nervous System Disorders.- 11 Nitric Oxide and Oxidative Damage in the CNS.- 12 Iron and Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury: Directions for Therapeutic Intervention.- 13 The Role of Oxidative Processes and Metal Ions in Aging and Alzheimer's Disease.- 14 Oxidative Stress with Emphasis on the Role of LAMMA in Parkinson's Disease.- 15 Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase.- 16 Tardive Dyskinesia and Oxidative Stress.- 17 Antioxidant Therapeutic Strategies in CNS Disorders.- 18 Oxidative Stress-Induced Cell Damage in the CNS: A Proposal for a Final Common Pathway.- Appendix Accepted Biomarkers of Oxidative Damage in Tissues.