Methods of Cancer Diagnosis, Therapy, and Prognosis

This seventh volume in the series discusses general methods, overviews, head and neck cancer, and thyroid cancer. Coverage should help in the development of more effective therapeutic approaches for the treatment of head and neck cancer and thyroid cancer.

There are more than 100 types of cancers In Part II, head and neck cancer is d- affecting all parts of the human body. cussed. The global number of annual new More than 11 million people are diagnosed cases of this malignancy is ~500,000. These with cancer every year, and it is estimated malignancies include oral squamous cell that there will be 16 million new cases by carcinoma, salivary gland tumors, tons- the year 2020. In 2005, 7. 6 million peo- lar cancer, tongue cancer, nasopharyngeal ple died of cancer, that is, 13% of the 58 carcinoma, and retinoblastoma, which are million deaths worldwide. It is estimated detailed. In Part III, diagnosis, therapy, and that 9 million people will die from can- prognosis of thyroid carcinoma are d- cer worldwide in 2015 and 11. 4 million cussed. The global number of new cases of will die in 2030. More than 70% of all thyroid cancer is ~141,000, and the number cancer deaths occur in low and middle of worldwide thyroid mortalities is ~35,375. income countries. These statistics underlie The number of new cases of this cancer in the fact that cancer is the deadliest of all the United States is ~33,550. Molecular human diseases. The enormity of the glo- genetics of thyroid cancer, gene expr- bal healthcare costs as a result of cancer sion markers for diagnosis, papillary t- cannot be overemphasized.

The only book that discusses cancer diagnosis, therapy, and prognosis together in one volume Discusses the molecular processes that lead to the development and proliferation of cancer cells Includes recent major advances in cancer diagnosis and therapy assessment The text is supported throughout with illustrations The information in the book identifies patients with high likelihood of clinical benefits from a specific treatment

Klappentext

The seventh volume of the series, Methods of Cancer Diagnosis, Therapy, and Prognosis, discusses General Methods, Overviews, Head and Neck Cancer, and Thyroid Cancer. As in the other six volumes of the series, these subjects are discussed in detail.

This fully illustrated volume presents overviews in

• Radio-immunotherapy in Cancer

• Multidrug Resistance

• Cancer Biomarkers

• Role of Antibodies in Cancer Treatment

• Classification of Cancer Stage Using Patient's Immune System

• Cancer Stem Cells

  General methods discussed are

• Translating In Vitro Cell Lines Result into Clinical Practice

• Late Relapse of Germ Cell Malignancies

• Role of RNA Interference in Understanding the Molecular Bases of Cancer

• Incorporating Pharmacogenomics into Cancer Therapy

• Tumor Angiogenesis in Cancer

• Spindle Cell Oncocytoma of the Adenohypophysis

• Chemotherapy-Induced Neurotoxicity

• Disseminated Carcinoma of Unknown Primary Site

• Unknown Lymphadenopathy

  In part 2 of this volume Head and Neck Squamous Cell Carcinoma, Early Stage Oral Squamous Cell Carcinoma, Salivary Gland Tumors, Retinoblastoma, Tongue Cancer Metastasis, Role of Human Papilloma Virus in Tonsillar Cancer and Nasopharyngeal Carcinoma are discussed.

  Part 3 discusses in detail Thyroid Carcinoma, including Papillary Thyroid Carcinoma,Molecular Genetics of the Thyroid, Medullary Thyroid Carcinoma, PET Imaging in Thyroid carcinoma, Thyroid Cancer and Markers for Diagnosis, Metastasized Medullary Thyroid Carcinoma, and Prognostic Factors in Thyroid Carcinoma.

  The information presented in this volumeshould help in the development of novel, more effective therapeutic approaches for the treatment of head and neck cancer and thyroid cancer.

  Professor Hayat has summarized the problems associated with the complexities of research publications and has been successful in editing a must-read volume for oncologists, cancer researchers, medical teachers and students of cancer biology.

  Inhalt
  General Methods and Overviews.- Role of RNA Interference in Understanding the Molecular Basis of Cancer.- Cancer Biomarkers (An Overview).- Tumor Angiogenesis in Cancers: Expression of CD105 Marker.- Spindle Cell Oncocytoma of the Adenohypophysis: Integrated Clinicopathologic Diagnosis by Imaging, Histology, and Immunohistochemistry.- Disseminated Carcinoma of Unknown Primary Site: Detection with F-Fluorodeoxyglucose-Positron Emission Tomography.- Unknown Lymphadenopathy: Diagnosing Using an Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy.- Pretargeted Radioimmunotherapy in Cancer: An Overview.- Chemotherapy-Induced Neurotoxicity.- Multidrug Resistance.- Role of Antibodies in Cancer Treatment (An Overview).- Incorporating Pharmacogenomics into Cancer Therapy.- Cancer Stem Cells: An Overview.- Translating In Vitro Cell Lines Result into Clinical Practice.- Classification of Cancer Stage Using Patient's Immune System.- Late Relapse of Germ Cell Malignancies: Incidence, Management, and Prognosis.- Head and Neck Cancer.- Head and Neck Squamous Cell Carcinoma: Therapy with Fusaric Acid/Paclitaxel.- Early Stage Oral Squamous Cell Carcinoma: Use of Signal Transducer and Activator of Transcription 3 as a Risk Factor for Poor Diagnosis.- Salivary Gland Tumors: Preoperative Tissue Characterization with Apparent Diffusion Coefficient Mapping.- Role of Human Papillomavirus in Tonsillar Cancer.- Quantitative Reverse TranscriptionPolymerase Chain Reaction Based Assessment of the Candidate Biomarkers for Tongue Cancer Metastasis.- Nasopharyngeal Carcinoma (Retropharyngeal Lymph Node Metastasis): Spread Pattern, Prognosis, and Staging.- Retinoblastoma: Diagnosis, Treatment and Prognosis.- Thyroid Carcinoma.- Molecular Genetics of Thyroid Cancer.- Thyroid Cancer:Identification of Gene Expression Markers for Diagnosis.- Papillary Thyroid Carcinoma: Use of HBME1 and CK19 as Diagnostic Markers.- Papillary Thyroid Carcinoma: Detection of Copy Gain of Platelet Derived Growth Factor B Using Array Comparative Genomic Hybridization in Combination with Laser Capture Microdissection.- PET Imaging in Thyroid Carcinoma.- Metastasized Medullary Thyroid Carcinoma: Detection and Therapy Using Radiolabeled Gastrin Analogs.- Medullary Thyroid Carcinoma: Prognosis based on Stage of Disease and Age.- Overexpression of the Components of the Plasminogen Activating System as Prognostic Factors in Human Thyroid Carcinoma.