Microglia in the Regenerating and Degenerating Central Nervous System

The study of microglial cells has recently gained importance for those researching degeneration and regeneration. Microglia in the Regenerating and Degenerating CNS supports the assertion that understanding microglial biology could perhaps be pivotal for unraveling the pathogenetic mechanisms that underlie Alzheimer's disease, In addition, microglia are also critical for understanding the sequelae of traumatic brain and spinal cord injury, and for the important post-traumatic repair processes. This book gives an up to date account of the role of microglia in degeneration and regeneration of the nervous system and reviews their cell function and physiology.

Inhalt

1. Physiology and Pathophysiology of Microglial Cell Function.- 2. Roles of Microglia in the Developing Avian Visual System.- 3. Microglial Ion Channels.- 4. Calcium Signaling in Microglial Cells.- 5. Microglia as a Source and Target of Cytokine Activities in the Brain.- 6. Microglia and Macrophage Responses in Cerebral Ischemia.- 7. Role of Microglia and Macrophages in Secondary Injury of the Traumatized Spinal Cord: Troublemakers or Scapegoats?.- 8. Microglial Response in the Axotomized Facial Motor Nucleus.- 9. Neuroprotective Roles of Microglia in the Central Nervous System.- 10. Influences of Activated Microglia/Brain Macrophages on Spinal Cord Injury and Regeneration.- 11. Opportunities for Axon Repair in the CNS: Use of Microglia and Biopolymer Compositions.- 12. Beta Amyloid Protein Clearance and Microglial Activation.- 13. Microglia and Aging in the Brain.