Microspheres -A novel drug delivery system for anticancer drugs

Microspheres is a novel drug delivery system which involves entrapment of a drug moiety in a polymeric membrane to alter the release profile of the drug. The present book provides a guide on development and evaluation methodology for microspheres for anticancer drug. Ethyl cellulose microsphere for anticancer drug 5-Flurouracil is selected as a model example. 5-FU is an antimetabolite and immunosuppressive agent. It is used in the treatment of breast, colon, stomach, pancreas, ovary, urinary bladder and lung cancers. But it has a rapid plasma clearance and a short half-life. The drug can be encapsulated in microspheres to prolong its residence time and thereby its action. The ethyl cellulose microspheres containing 5-FU were prepared by a w/o/w emulsification solvent evaporation technique. The process variables in the preparation of 5- FU loaded ethyl-cellulose microspheres were optimized.A factorial design was employed to evaluate the effect of the selected independent variables on some in-vitro attributes of microspheres. Accelerated stability studies of 5- FU loaded ethyl cellulose microspheres was performed.

Autorentext

Nitin Dubey is actively involved in various academic and research activities in the field of analytical method development, herbal drug standardization and drug delivery systems from last 10 years. He is a reviewer of many international pharmacy journals of repute and have many international/ national publications to his credit.