Midkine: From Embryogenesis to Pathogenesis and Therapy

Carl Edward Sagan's (1934-1996) one of the famous quotation was Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people. From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named Midkine This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as botha pathologic factor and therapeutic agent.

Comprehensive coverage of old, but newly pronounced protein midkine as a promising prognostic and diagnostic biomarker, and a therapeutic agent in wide range of diseases Provides an information about the techniques that are used in studying midkine Leading experts present their latest work in addition to extensive up-to-date literature review

Klappentext

Carl Edward Sagan s (1934-1996) one of the famous quotation was Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people. From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named Midkine This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as botha pathologic factor and therapeutic agent.

Inhalt

PART I: General aspects of mdkne.-1 General information on midkine.-2The role of midkine in neural development and patterning.-3Midkine- A player in innate immunity.-4 Midkine/p63 axis in regulation of epithelial-mesenchymal transition.-5 Immunochemical methods for the detection of midkine in samples of human origin.-6 Circulating midkine in malignant, inflammatory, and infectious diseases: a systematic review.II Mdkne and nflammaton.-7 Midkine in inflammation and inflammatory diseases.-8 Rheumatoid arthritis and midkin.III Mdkne and the cardovascular system.-9 Midkine and heart failure.-10 Vascular restenosis and midkine.-11 The potential of MK through the renin-angiotensin system.IV Mdkne and the nervous system.-12 Midkine and Multiple sclerosis.-13 MK gene transfer in brain infarction.-14 Midkine in psychiatric and neurodegenerative diseases.V Mdkne and the urogental system, reproducton and agng.-15 Role of midkine in nephrogenesis and kidney Disease.-16 Midkine, a factor promoting cytoplasmic maturation of oocytes.-17 Endometriosis may be promoted by midkine: possible involvement of ovarian follicles.-18 Stem cells and midkine.-19 Midkine in skeletal physiology.VI Mdkne and cancer.-20 Midkine and chemotherapy resistance in cancers.-21 A gene medicine with the midkine transcriptional regulation as new cancer therapeutics.-22 Midkine as a tumor shared antigen.-23 Midkine in prostate cancer.-24 Midkine is a potential therapeutic target of hepatocellular carcinoma.-25 Midkine in glioblastoma with the modulator role switching autophagy to cell death or cell survival.-26 Colon cancer and midkine.-27 Osteosarcoma and midkine.Index.