Mitochondrial Dynamics and Neurodegeneration

Written by experts, this book offers comprehensive coverage of the mechanisms of mitochondrial dynamics, from basic research on its molecular basis to medical implications, to the direction of future research. Includes numerous color figures and illustrations.

Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer's, Parkinson's, and Huntington's diseases.

Comprehensive reviews written by leading researchers in the field Numerous color figures and illustration to help the readers to better grasp the topics A chapter on mitophagy, one of the most intensely studied topics in neurodegenerative diseases research Includes supplementary material: sn.pub/extras

Inhalt

1. Genetics of mitochondrial fission and fusion; 2. Relationship between mitochondrial dynamics and bioenergetics; 3. Mitochondrial dynamics and autophagy; 4. Mitochondrial dynamics and apoptosis; 5. Mitochondrial dynamics and axonal transport; 6. Mutations in mitochondrial fusion machinery linked to neurological diseases; 7. Mitochondrial dynamics and Parkinson's disease; 8. Mitochondrial fission and fusion defects in Alzheimer's disease; 9.** Mitochondrial dynamics and Huntington's disease.