Modelling Survival Data in Medical Research

Fourth edition has new chapters on Bayesian survival analysis and use of the R software. Chapters extensively revised, expanded to add new material on topics that include methods for assessing predictive ability of a model, joint models for longitudinal and survival data, modern methods for the analysis of interval-censored survival data.

Modelling Survival Data in Medical Research, Fourth Edition, describes the analysis of survival data, illustrated using a wide range of examples from biomedical research. Written in a non-technical style, it concentrates on how the techniques are used in practice. Starting with standard methods for summarising survival data, Cox regression and parametric modelling, the book covers many more advanced techniques, including interval-censoring, frailty modelling, competing risks, analysis of multiple events, and dependent censoring.

This new edition contains chapters on Bayesian survival analysis and use of the R software. Earlier chapters have been extensively revised and expanded to add new material on several topics. These include methods for assessing the predictive ability of a model, joint models for longitudinal and survival data, and modern methods for the analysis of interval-censored survival data.

Features:

• Presents an accessible account of a wide range of statistical methods for analysing survival data
• Contains practical guidance on modelling survival data from the author's many years of experience in teaching and consultancy
• Shows how Bayesian methods can be used to analyse survival data
• Includes details on how R can be used to carry out all the methods described, with guidance on the interpretation of the resulting output
• Contains many real data examples and additional data sets that can be used for coursework

• All data sets used are available in electronic format from the publisher's website Modelling Survival Data in Medical Research, Fourth Edition, is an invaluable resource for statisticians in the pharmaceutical industry and biomedical research centres, research scientists and clinicians who are analysing their own data, and students following undergraduate or postgraduate courses in survival analysis.

  Autorentext

David Collett obtained his first degree at the University of Leicester, before going on to complete an MSc in statistics at the University of Newcastle and a PhD in statistics at the University of Hull. David was a lecturer and senior lecturer in the Department of Applied Statistics at the University of Reading for over 25 years, including eight years as head of that department. In 2003, he was appointed Associate Director of Statistics and Clinical Studies at NHS Blood and Transplant. This involved supervising the statistical work of over 30 staff and collaborative work with transplant clinicians and research scientists. David became Director of the NHS Blood and Transplant Clinical Trials Unit, responsible for the design, conduct and analysis of clinical trials in transplantation and transfusion medicine. He also held a visiting chair in the Southampton Statistical Sciences Research Institute, University of Southampton, until his retirement. He now likes to spend as much time as possible on the golf course.

Inhalt

1. Survival analysis 2. Some non-parametric procedures 3. The Cox regression model 4. Model checking in the Cox regression model 5. Parametric regression models 6. Flexible parametric models 7. Model checking in parametric models 8. Time-dependent variables 9. Interval-censored survival data 10. Frailty models 11. Non-proportional hazards and institutional comparisons 12 Competing risks 13. Multiple events and event history modelling 14. Dependent censoring 15. Sample size requirements for a survival study 16. Bayesian survival analysis 17. Survival Analysis with R