Modern Trends in Virology

In June 1986 a symposium was held in Giessen on Modern Trends in Virology. It was initiated by the Deutsche Forschungsgemeinschaft, which had supported virus research for the past 18 years in the Sonderforschungsbereich 47 at the University of Giessen. The purpose of the meeting was to serve as a forum for the members of the Sonderforschungsbereich to discuss scientific topics of mutual interest with about 200 virologists that had come from various parts of Europe, the United States, and Japan. It was not by chance that the symposium took place shortly after the 60th birthday of Rudolf Rott, who had founded the Sonderforschungsbereich in 1968 and has been its speaker ever since. Without his vision and his never resting energy Giessen would not have gained the position in the field of virology that it has today. This Festschrift, which contains the contributions presented at the plenary sessions of the symposium, is therefore dedicated to Rudolf Rott. HEINZ BAuER HANS-DIETER KLENK CHRISTOPH SCHOLTISSEK Table of Contents A Genetic Approach to Determining Glycoprotein Topology: The Influenza B Virus NB Glycoprotein has an Extracellular NHz-Terminal Domain Containing two N-linked Carbohydrate Chains R. A. LAMB and M. A. WILLIAMS . . . . . . . . . . . . . . . . . . . . . . . . . 1 Paramyxovirus Metabolisms Associated with the Cytoskeletal Framework Y. NAGAI, T. ToYODA, and M. HAMAGUCHI . . . . . . . . . . . . . . . . . . . 15 Correlation of High Evolutionary Rate of Influenza A Viruses in Man with High Mutation Rate Measured in Tissue Culture: A Hypothesis P. PALESE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Klappentext

Leading research in the active field of virology is given coverage in this volume. Based on contributions from a meeting in Giessen, FRG, organized by the Deutsche Forschungsgemeinschaft, the reviews represent international experience from Japan, Europe and North America. The most interesting topics in current virus research are included, such as: leukemogenesis by retroviruses, coding strategy of arena- and coronaviruses, slow virus infections, virus-induced membrane fusion, antiviral agents, pathogenetic mechanisms of influenza- and retroviruses, and recombinant vaccinia virus.

Inhalt
A Genetic Approach to Determining Glycoprotein Topology: The Influenza B Virus NB Glycoprotein has an Extracellular NH2-Terminal Domain Containing two N-linked Carbohydrate Chains.- Paramyxovirus Metabolisms Associated with the Cytoskeletal Framework.- Correlation of High Evolutionary Rate of Influenza A Viruses in Man with High Mutation Rate Measured in Tissue Culture: A Hypothesis.- Cell Binding and Membrane Fusion Activities of Influenza Viruses.- Molecular Characterization of H5N2 Influenza Viruses from Chickens.- Viruses, Amyloidosis, and Dementia: Prospects for Unconventional Slow Infections.- Mechanism of Recovery from Acute Virus Infection.- Coronavirus Infection of Rats: A Model for Virus-Induced Demyelinating Disease Associated with Autoimmunity.- Structural Proteins of the Murine Coronavirus MHV-JHM.- Molecular Cloning of Flavivirus Genomes for Comparative Analysis and Expression.- The Ambisense Coding Strategy of the S RNA of Arenaviruses.- Common Events in Mitogenic and Oncogenic Pathways.- Molecular Basis for the Pathogenicity of the Friend Spleen Focus-Forming Virus.- Leukemogenesis by Transactivating Retroviruses: Bovine Leukemia Virus as a Model System.- The Structure and Function of Reovirus Genes.- Selective Inhibition of Virus Replication.- Recombinant Vaccinia Viruses: New Applications of an Old Vaccine.