Modular synthesis of well-defined macromolecular architectures

Click chemistry, and the copper(I)-catalyzed
cycloaddition of azides and terminal alkynes in
particular, has recently taken a tremendous flight in
the field of polymer chemistry. One of the main
reasons for this revolution stems from the fact that
scientists want to gain control over polymer
structures in order to adapt to a specific
application environment. Nowadays, a wide range of
living and controlled polymerization techniques is
available to prepare polymer architectures with a
large variety of distinct topologies, functionality,
predetermined degree of polymerization and narrow
molecular weight distribution. In combination with
specific and efficient coupling chemistry, like a
"click" reaction, macromolecular architectures can be
synthesized which are hard to assess otherwise. In
this respect "click" chemistry absolutely has added
value in polymer science...
This book reviews the use of the copper(I)-catalyzed
cycloaddition of azides and alkynes along with the
controlled radical polymerization technique atom
transfer radical polymerization. This methodology was
applied in order to prepare AB and ABC type block
copolymers, macrocyclic polymers and to attach
biomolecules.

Autorentext

Dr. Joost Opsteen studied chemistry at the Raboud UniversityNijmegen where he also obtained his PhD degree. After apostdoctorial period in the bio-organic chemistry department incollaboration with the orthopaedic research laboratory of theRadboud University Medical Center Nijmegen, he moved to industry.He is currently working at Encapson B.V.

Klappentext

"Click" chemistry, and the copper(I)-catalyzedcycloaddition of azides and terminal alkynes inparticular, has recently taken a tremendous flight inthe field of polymer chemistry. One of the mainreasons for this revolution stems from the fact thatscientists want to gain control over polymerstructures in order to adapt to a specificapplication environment. Nowadays, a wide range ofliving and controlled polymerization techniques isavailable to prepare polymer architectures with alarge variety of distinct topologies, functionality,predetermined degree of polymerization and narrowmolecular weight distribution. In combination withspecific and efficient coupling chemistry, like a"click" reaction, macromolecular architectures can besynthesized which are hard to assess otherwise. Inthis respect "click" chemistry absolutely has addedvalue in polymer science...This book reviews the use of the copper(I)-catalyzedcycloaddition of azides and alkynes along with thecontrolled radical polymerization technique atomtransfer radical polymerization. This methodology wasapplied in order to prepare AB and ABC type blockcopolymers, macrocyclic polymers and to attachbiomolecules.