Molecular and Cellular Pediatric Endocrinology

Stuart Handwerger, MD and a distinguished panel of clinicians and experts review the most significant recent developments in molecular and cellular biology, powerful advances that have produced new diagnostic methods and improved treatments for many pediatric endocrine diseases. Topics range from the growth hormone/prolactin/placental lactogen gene family and their regulation of growth, to steroid hormones, sexual development, and mineral corticoid action. Additional chapters examine the pathophysiology of insulin-dependent diabetes mellitus, the molecular genetics of thyroid cancer, the molecular basis of hypophosphatemic rickets, and inherited diabetes insipidus. Molecular and Cellular Pediatric Endocrinology offers today's clinicians and researchers not only the latest findings on endocrine diseases in their pediatric manifestations, but also highly practical insights into today's cutting-edge diagnostics, treatment strategies, and powerful new therapeutics.

Zusammenfassung
". . . overview[s] the most rapidly developing areas of advances in molecular advances and their applications to the study, diagnosis, and treatment of pediatric endocrine disorders. The first seven chapters focus on the regulation of growth and the growth hormone/prolactin/placental lactogen gene family. Steroid hormones, sexual development, and mineralacortoid action are discussed in the next five chapters (including a review of the first human case of estrogen receptor defects). The pathophysiology of diabetes mellitus is the subject of two chapters. The rest of the text treats the molecular genetics of thyroid cancer, hypophosphatemic rickets, and inherited diabetes insipidus."-SciTech Book News

". . .cuts a wide and deep swath through the basic biology and pathology of the disorders [pediatric endocrinologists] deal with in the clinic every day. No matter your disease(s) of interest, its molecular/cellular basis is covered in this mutiauthored book. . . well referenced."-PedEndoGram

"A useful addition to clinical pediatric endocrinology and of interest also to geneticists."-Journal of Pediatric Endocrinology and Metabolism

Inhalt
1 Molecular Basis of Disorders of Sexual Differentiation.- 2 Insulin-Like Growth Factor Control of Growth: Insights from Targeted Disruption of Murine Genesand from Human Disease.- 3 Molecular Defects in the Growth Hormone Axis.- 4 The Molecular Basis of Hypophosphatemic Rickets.- 5 The Roles of Growth Hormone, Prolactin, and Placental Lactogen in Human Fetal Development: Critical Analysis of Molecular, Cellular, and Clinical Investigations.- 6 Growth Hormone Releasing Hormone: Biological and Molecular Aspects.- 7 The Glomerular Physiology of Diabetic Nephropathy.- 8 P450c17 The Qualitative Regulator of Steroidogenesis.- 9 The Molecular Basis of Inherited Diabetes Insipidus.- 10 Molecular Biology of Gonadotropin-Releasing Hormone and the Gonadotropin-Releasing Hormone Receptor.- 11 Estrogen Biology: Evolving New Concepts.- 12 Molecular Genetics of Thyroid Cancer: Evidence That Inactivationof Tumor Suppressor Genes Occurs at Late Stages of TumorProgression.- 13 The Molecular Basis of Mineralocorticoid Action.- 14 Molecular Aspects of Pituitary Development.- 15 Physiology and Molecular Biology of Placental Lactogen in Human Pregnancy.- 16 Molecular and Cellular Basis of Immune-Mediated (Type 1) Diabetes.- 17 Molecular Basis of Multiple Pituitary Hormone Deficiency.