Molecular and Computational Modeling of Cardiac Function

In Molecular and Computational Modeling of Cardiac Function, a group of prominent professors and researchers explain the fundamental concepts of molecular modeling and illustrate the biomedical applications. The book covers the following topics:

• Principles of atomistic modeling and simulation of biomolecular systems.
• Using atomistic modeling to predict the cardiotoxicity of an arrhythmia drug molecule.
• Bifurcation phenomena in cardiac system as control design of automaticity and arrhythmia.
• Modeling the role of myoglobin as a fatty acid transporter.

• Population-based computational approaches to investigate cardiac arrhythmia.

  Presents fundamental molecular modeling concepts and illustrates cardiac function applications Highlights recent advances in modeling, bifurcation, fatty acid transport, and population-based approaches Illustrates biomedical applications in discovering novel cardiac arrythmia drugs

  Autorentext

Thomas Jue is a Professor of Biochemistry and Molecular Medicine at the University of California Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to redesign a graduate curriculum that balanced physical science/mathematics formalism and biomedical perspective and has continued to promote interdisciplinary interest at the interface of physical science, engineering, mathematics, biology, and medicine. The Handbook of Modern Biophysics represents an aspect of that effort.

Klappentext

The Handbook of Modern Biophysics series focuses on current biophysics topics and presents fundamental concepts and biomedical application in biology, medical, engineering, mathematics, and physical-science students or researchers. The reader can learn to use novel biophysics techniques to address a range of research challenges. Each chapter develops the conceptual framework of the physics formalism and illustrates the biomedical applications. With the addition of problem sets, guides to further study, and references, the interested reader can continue to independently explore the ideas presented in the chapters.

Volume 7: Molecular and Computational Modeling of Cardiac Function
Editor Thomas Jue, PhD

In Molecular and Computational Modeling of Cardiac Function, a group of prominent professors and researchers explain the fundamental concepts of molecular modeling and illustrate the biomedical applications. The book covers the following topics:

• Principles of atomistic modeling and simulation of biomolecular systems.
• Using atomistic modeling to predict the cardiotoxicity of an arrhythmia drug molecule.
• Bifurcation phenomena in cardiac system as control design of automaticity and arrhythmia.
• Modeling the role of myoglobin as a fatty acid transporter.
• Population-based computational approaches to investigate cardiac arrhythmia. About the Editor

Thomas Jue is Professor of Biochemistry and Molecular Medicine at the University of California Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to redesign a graduate curriculum that balanced physical science/mathematics formalism and biomedical perspective and has continued to promote interdisciplinary interest at the interface of physical science, engineering, mathematics, biology, and medicine. The Handbook of Modern Biophysics represents an aspect of that effort.

Inhalt

Introduction to Atomistic Modeling and Simulation of Biomolecular Systems.- Investigating.- Cardiovascular Function Modulation via Atomistic Modeling and Simulations.- Bifurcation Phenomena in Cardiac System and Its Analyzes.- Modeling and simulation of drug actions on cardiac ion channels and myocytes.- Modeling the Function of Myoglobin in Myocardium.- Population based computational approaches to investigate cardiac arrhythmia risk.