Molecular and Translational Vascular Medicine

Providing fresh insights into the mechanisms of the classic vascular pathophysiologic processes, such as angiogenesis, atherosclerosis, thrombosis, and vasculitis, this book also covers new research fields including the role of the ubiquitin proteasome system.

Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases.

Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.

Provides new insights into vascular pathophysiologic processes Covers the emerging field of therapeutic angiogenesis All chapters are written by experts in their fields Includes supplementary material: sn.pub/extras

Autorentext

Jonathon W. Homeister, MD, PhD

McAllister Heart Institute, The University of North Carolina School of Medicine, Chapel Hill, NC, USA

Monte S. Willis, MD, PhD

McAllister Heart Institute, The University of North Carolina School of Medicine, Chapel Hill, NC, USA

Inhalt
The Molecular Biology and Genetics of Aneurysms.- The Molecular Biology and Treatment of Systemic Vasculitis in Children.- Recent Insights into the Molecular and Cellular Contributions to Venous Thrombosis.- The Ubiquitin Proteasome System in Endothelial Cell Dysfunction and Vascular Disease.- Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis.- Molecular Regulation of Vasculogenesis and Angiogenesis: Recent Advances and Future Directions.- Therapeutic Angiogenesis for Critical Limb Ischemia: Complex Mechanisms and Future Challenges.- Modulating the proliferative response to treat restenosis after vascular injury.- Cardiovascular Nanomedicine: Challenges and Opportunities.- Endothelial Progenitor Cells in the Treatment of Vascular Disease.