Molecular Aspects of Hematologic Malignancies

This book surveys the molecular biology of hematologic malignancies in relation to clinical diagnoses, symptoms and therapies, including aspects of applied methodology. Offers up-to-date coverage of the molecular basis of selected hematologic disorders.

This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors' own laboratories.

Up-to-date information on the molecular basis of selected hematologic disorders Practical reference for molecular laboratory procedures Of interest to clinical oncologists and hematologists as well as to graduates in molecular medicine, human genetics and laboratory medicine Includes supplementary material: sn.pub/extras

Inhalt

This book consists of 29 chapters and is divided into the following four Parts: Part I Molecular biology of Selected Hemato-oncologic Diseases.- Part II Diagnostics and Monitoring of Therapy of Hemato-oncologic Diseases.- Part III Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation.- Part IV Molecular Diagnostic Protocols.