Molecular Biology of Neurodegenerative Diseases: Volume 107

Informationen zum Autor David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid ß-protein (Alzheimer's disease) and a-synuclein (Parkinson's disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Co-Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease. Klappentext Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells, which leads to problems with movement and mental functioning. Examples include Parkinson s, Alzheimer s and Huntington s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. PRAISE FOR THE SERIES "Full of interest not only for the molecular biologist--for whom the numerous references will be invaluable--but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--British Medical Journal Zusammenfassung Neurodegenerative diseases result in progressive degeneration and/or death of nerve cells which leads to problems with movement and mental functioning. This volume reviews the research and developments in the molecular biology of neurodegenerative diseases. Inhaltsverzeichnis Neuropathology and imaging Harry Vinters Neuropathology and imaging Thompson, Paul Age-dependence of neurodegenerative diseases (organismal genetics) Tanzi, Rudolph AD Dominic Walsh PD Guo, Ming PD Rochet, Chris and Prion I: Human Surewicz, Witold Prion II: Yeast Tuite, Mick Cerebral amyloid angiopathy Cerebral amyloid angiopathy Yamada, Masahito Naiki, Hironobu Tau, and Gloria Lee Membrane Pores Kagan, Bruce Unfolded protein response ALS Dokholyan, Nikolay CAG-repeat diseases Chris Ross Mitochondria Lee Martin...

Autorentext

David B. Teplow, Ph.D., is a Professor of Neurology, Emeritus, at UCLA and an internationally recognized leader in efforts to understand and treat Alzheimer's disease. Dr. Teplow's group has used a multi-disciplinary approach to determine how neurotoxic peptides, such as the amyloid ß-protein (Alzheimer's disease) and a-synuclein (Parkinson's disease), form neurotoxic structures that kill neurons and to develop the means to block these processes. Dr. Teplow received undergraduate training at UC Berkeley; a Ph.D. from the University of Washington; and was a postdoctoral scholar at Caltech. Before coming to UCLA, Dr. Teplow was a faculty member in the Department of Neurology, Harvard Medical School. Dr. Teplow has published >250 peer-reviewed articles, books and book chapters, and commentaries, in addition to serving on numerous national and international scientific advisory boards. Dr. Teplow was a founding editor of the Journal of Molecular Neuroscience and Current Chemical Biology, He is Co-Editor-in-Chief of the Elsevier serial Progress in Molecular Biology and Translational Science and is Associate Editor-in-Chief of the American Journal of Neurodegenerative Disease.

Klappentext

Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells, which leads to problems with movement and mental functioning. Examples include Parkinson s, Alzheimer s and Huntington s disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases.

Zusammenfassung
Neurodegenerative diseases result in progressive degeneration and/or death of nerve cells which leads to problems with movement and mental functioning. This volume reviews the research and developments in the molecular biology of neurodegenerative diseases.

Inhalt

1. Neuropathology and imaging Harry Vinters
2. Neuropathology and imaging Thompson, Paul
3. Age-dependence of neurodegenerative diseases (organismal genetics) Tanzi, Rudolph
4. AD Dominic Walsh
5. PD Guo, Ming
6. PD Rochet, Chris and
7. Prion I: Human Surewicz, Witold
8. Prion II: Yeast Tuite, Mick
9. Cerebral amyloid angiopathy Cerebral amyloid angiopathy Yamada, Masahito Naiki, Hironobu Tau, and Gloria Lee
10. Membrane Pores Kagan, Bruce
11. Unfolded protein response
12. ALS Dokholyan, Nikolay
13. CAG-repeat diseases Chris Ross
14. Mitochondria Lee Martin