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Molecular Characterization of Salmonella Paratyphi A from Bangladesh
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Geliefert zwischen Do., 13.11.2025 und Fr., 14.11.2025
Details
Strains of Salmonella Paratyphi A isolated from the patients admitted to the diarrhoea treatment center of ICDDR, B were characterized both at the phenotypic and genotypic levels. Antibiotic susceptibility test revealed that 61% of the strains (n = 19) were sensitive to all the antibiotics used for empirical treatment of paratyphoid fever and 32% strains (n = 10) were resistant only to nalidixic acid. Most of the strains that showed reduced susceptibility to ciprofloxacin, having elevated MIC value (0.5µg/ml). A point mutation in the gyrA gene was observed at codon 83 (TCC to TTC), which substitutes phenylalanine for. This clearly indicates that a significant number of the S. Paratyphi A strains with reduced susceptibility to ciprofloxacin has been evolved. Of 31 strains, 16 (52%) of S. Paratyphi A strains harbored 35 MDa middle-ranged and non-conjugative plasmid. Pulse-field gel electrophoresis (PFGE) revealed that most of the strains (83%) were clonal regardless of antimicrobial sensitivity patterns.
Weitere Informationen
- Allgemeine Informationen
- Sprache Englisch
- Autor Muhammad Asaduzzaman , Nishat Nasrin
- Titel Molecular Characterization of Salmonella Paratyphi A from Bangladesh
- ISBN 978-3-639-28858-2
- Format Kartonierter Einband (Kt)
- EAN 9783639288582
- Jahr 2010
- Größe H220mm x B150mm x T7mm
- Untertitel Antibiotic Susceptibility and Molecular Characterization of Salmonella Paratyphi A Isolated in Bangladesh
- Gewicht 197g
- Genre Medizin
- Anzahl Seiten 120
- Herausgeber VDM Verlag Dr. Müller e.K.
- GTIN 09783639288582
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