Molecular Insight into Human Platelet Antigen HPA-1 Polymorphism

Human platelet HPA-1 polymorphism is embedded in the N-terminal plexin/semaphorin/integrin (PSI) domain of the beta3 chain of the platelet integrin IIbbeta3. HPA-1 polymorphism is responsible for neonatal alloimmune thrombocytopenia (NAITP). T-helper response drives anti-HPA-1a production and the putative dominant T-helper epitope is likely to be an important contributory factor in the immunogenicity of HPA-1a. This book provides detailed insight into the molecular mechanism behind of anti-HPA-1a platelet alloimmunization.

Autorentext

Gholamreza Anani Sarab (PhD, MSc, PG Diploma). Assistant Professor in Birjand University of Medical Sciences. PhD in Immunohaematology, University of Aberdeen-UK. Postgraduate Diploma in Medical Molecular Genetics, University of Aberdeen-UK. MSc in Medical Immunology, Tehran University of Medical Sciences, Tehran-Iran.