Molecular Medicine

Extensively updated, the new edition of this pioneering textbook for Molecular Medicine covers 14 modules from molecular diagnostics to precision medicine approaches, stem cells, and gene therapy.

Ein sehr gut strukturiertes, übersichtliches und sehr aktuelles Lehrbuch mit sehr gut erklärenden Abbildungen. (Dr. Ursula Hoja, Paracelsus Medizinische Universität, Nürnberg)

Autorentext
Jens Kurreck is full Professor for Applied Biochemistry at the Berlin University of Technology (TUB), Germany. He studied biochemistry and philosophy at the Free University of Berlin (FUB) and completed his PhD at the TUB in 1998. His research focuses on RNA technologies, pain research and virology.

Cy A. Stein is Professor of Oncology and Experimental Therapeutics at the City of Hope Medical Center in Duarte, CA, USA. He received a Ph.D. in chemistry from Stanford University and the M.D. degree at the Albert Einstein College of Medicine, NY, in 1982. He has received numerous awards, among them the Clinical Career Development Award of the American Cancer Society.

Klappentext

Discover the future of medicine in this extensively updated edition of the pioneering textbook, reflecting the rapid progress in the field Molecular medicine is a rapidly growing field, and the molecular basis of diseases can be used to develop therapeutic approaches in numerous other medical subfields. Research into molecular medicine has been used as the basis for gene therapy, precision medicine, and more. Molecular Medicine provides a fundamental overview of this cutting-edge, interdisciplinary field, incorporating modules from basic immunology to virology to new approaches. Now fully updated to reflect the exponential progress in biomedical research, it promises to put students on the leading edge of a revolution in the life sciences. Readers of the second edition of Molecular Medicine will also find:

• Detailed discussion of cutting-edge topics including cancer stem cells, mRNA vaccines, organs-on-a-chip, and more
• Professional artwork throughout

• Chapter summaries, exercises, and study questions for each chapter Molecular Medicine is ideal for graduate students in life sciences and medicine, as well as the lecturers and libraries that support them.

  Inhalt
  1 Introduction
  1.1 The Basics of Molecular Medicine
  1.2 The Human Cell
  1.3 DNA Replication and Gene Expression
  1.4 Biological Communication
  1.5 The Immune System
  2 Methods in Molecular Medicine
  2.1 DNA Microarrays
  2.2 Quantitative Polymerase Chain Reaction
  2.3 Next-Generation Sequencing
  2.4 Proteomics
  2.5 Animal Models in Biomedical Research
  2.6 Alternatives to Animal Testing
  2.7 Additional Methods
  3 Genetic Disorders
  3.1 Single-Gene Disorders
  3.2 Polygenic Disorders
  4 Molecular Oncology
  4.1 Basics of Oncology
  4.2 Selected Cancer Diseases
  4.3 Oncolytic Virus Therapy
  4.4 Cancer Stem Cells
  4.5 Cancer Immunotherapy
  5 Molecular Virology
  5.1 The Basics of Virology
  5.2 Vaccination
  5.3 Detection of Viruses
  5.4 Antiviral Therapy
  5.5 Prions
  6 Bacteria and Eukaryotic Pathogens
  6.1 Bacteria
  6.2 Eukaryotic Pathogens
  7 Genomics and Proteomics
  7.1 Whole Genome Sequencing
  7.2 The Human Genome
  7.3 Sequencing of Ancient DNA
  7.4 Follow-up Initiatives of the Human Genome Project
  8 Genetic Testing
  8.1 Types of Genetic Tests
  8.2 Chromosome Abnormalities
  8.3 Molecular Diagnosis
  9 Pharmacogenetics/Pharmacogenomics
  9.1 Uptake and Transport of Drugs
  9.2 Drug Metabolism
  9.3 Drug Targeting
  9.4 Drug Toxicity and Hypersensitivity
  9.5 Drug Development and Individual Pharmacotherapy
  10 Recombinant Protein Drugs
  10.1 Production of Recombinant Proteins
  10.2 Classes of Recombinant Drugs
  11 Gene Therapy
  11.1 Types of Gene Therapy
  11.2 Methods of Gene Transfer
  11.3 Tissue Specificity of Gene Transfer and Gene Expression
  11.4 Applications of Gene Therapy
  11.5 Genome Editing with CRISPR/Cas
  11.6 Future Prospects
  12 Stem Cells
  12.1 Embryonic Stem Cells
  12.2 Adult Stem Cells
  12.3 Induced Pluripotent Stem Cells
  12.4 Transdifferentiation and Direct Reprogramming
  12.5 Differentiation of Stem Cells
  12.6 Medical Applications of Stem Cells
  13 Oligonucleotide-based Strategies
  13.1 Antisense Oligonucleotides
  13.2 RNA Interference
  13.3 MicroRNAs
  13.4 Aptamers, Decoy Oligonucleotides, and Immunostimulatory Oligonucleotides
  14 Ethics in Molecular Medicine
  14.1 The Basis of Bioethics
  14.2 Fields of Application