Molecular Oncology Diagnostics, An Issue of the Clinics in Laboratory Medicine: Volume 42-3

In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care.

• Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more.

• Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice.

• Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

  Inhalt

  Panel Sequencing for Targeted Therapy Selection in Solid TumorsMolecular Diagnostic Testing for Hematopoietic Neoplasms: Linking Pathogenic Drivers to Personalized DiagnosisSpecial Considerations in the Molecular Diagnostics of Pediatric NeoplasmsSpecimen Considerations in Molecular Oncology TestingUtility of Single-Gene Testing in Cancer SpecimensAnalytical Principles of Cancer Next Generation SequencingPrinciples and Validation of Bioinformatics Pipeline for Cancer Next-Generation SequencingBest Practice for Clinical Somatic Variant Interpretation and ReportingMolecular Detection of Oncogenic Gene RearrangementsCopy Number Analysis in Cancer Diagnostic TestingMolecular Biomarkers of Response to Cancer ImmunotherapyWhen Tissue Is the Issue: Expanding Cell-Free DNA "Liquid Biopsies? to Supernatants and Nonplasma BiofluidsGermline Testing for the Evaluation of Hereditary Cancer Predisposition