Molecular Pathogenesis and Signal Transduction by Helicobacter pylori

This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike.

Includes the latest studies on Helicobacter pylori, a human pathogen that infects ca. 50% of the world population Sheds new light on the risk factors of gastric disease and stomach cancer Presents hot novel models and signaling mechanisms Includes supplementary material: sn.pub/extras

Autorentext

Dr. rer. nat. Nicole Tegtmeyer
**Prof. Dr. rer. nat.Steffen Backert
**Chair of Microbiology
Friedrich Alexander University Erlangen/Nuremberg
Department of Biology, Division of Microbiology
Staudtstr. 5
91058 Erlangen
Germany

Inhalt

The human stomach in health and disease: infection strategies by Helicobacter pylori.- Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases.- Immune evasion strategies and persistence of Helicobacter pylori.- Recent advances in Helicobacter pylori replication: possible implications in adaptation to a pathogenic lifestyle and perspectives for drug design.- The Helicobacter pylori Methylome: Roles in Gene Regulation and Virulence.- Structural insights into Helicobacter pylori Cag protein interactions with host cell factors.- Gastric organoids: An emerging model system to study Helicobacter pylori pathogenesis.- DNA Transfer and Toll-Like Receptor Modulation by Helicobacter pylori.- Exploiting the gastric epithelial barrier: Helicobacter pylori's attack on tight and adherens junctions.- Helicobacter pylori-induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease.- Impact of the microbiota and gastric disease development by Helicobacter pylori.- Pathogenesis of gastric cancer: genetics and molecular classification.- Helicobacter pylori-mediated genetic instability and gastric carcinogenesis.- Helicobacter pylori and extragastric diseases.