Molecular Sensors for Cardiovascular Homeostasis

This book is aimed at providing the state-of-the-art reviews which define how the biologic systems sense changes in environment, alter their activities or function, and cross talk with other neurohormonal systems to modulate cardiovascular/renal function and blood pressure.

The biomolecular basis underlying essential hypertension and end organ damage associated with hypertension is characterized as polygenic diseases with complexities such as "environment gene" and "gene-gene" interactions. Despite intensive research in this field, this molecular book is aimed at providing the state-of-the-art reviews which define how the biologic systems sense changes in environment, alter their activities or function, and cross talk with other neurohormonal systems to modulate cardiovascular/renal function and blood pressure. This title will attract a vast range of readers including scientists and investigators in both academic and industrial fields, and clinicians. Graduate students will also be interested in buying this book, particularly as there is exponential growth of courses on this subject.

This title will attract a vast range of readers including scientists and investigators in both academic and industrial fields and clinicians Graduate students will also be interested in buying this book, particularly as there is exponential growth of courses on this subject

Inhalt
The DEG/ENaC Family.- The Role of DEG/ENaC Ion Channels in Sensory Mechanotransduction.- ASICs Function as Cardiac Lactic Acid Sensors During Myocardial Ischemia.- Molecular Components of Neural Sensory Transduction.- The TRP Family.- TRP Channels as Molecular Sensors of Physical Stimuli in the Cardiovascular System.- TRPV1 in Central Cardiovascular Control.- TRPV1 as a Molecular Transducer for Salt and Water Homeostasis.- Functional Interaction Between ATP and TRPV1 Receptors.- TRPV4 and Hypotonic Stress.- Other Ion Channels and Biosensors.- Ion Channels in Shear Stress Sensing in Vascular Endothelium.- Redox Signaling in Oxygen Sensing by Vessels.- Impedance Spectroscopy and Quartz Crystal Microbalance.