Molecules in Time and Space

During the last decade a wealth of new data has arisen from the use of new fluorescent labelling techniques and the sequencing of whole microbial genomes. One important conclusion from these data is that bacterial cells are much more structured than previously thought. The wall and the outer membrane contain topological domains, some proteins localize or move in specific patterns inside the cells, and some genes appear clustered in the chromosome and form conserved evolutionary units. Many of these structures are related to the cell cycle and to the process of cell morphogenesis, two processes that are themselves related to each other. From these observations the dcw gene cluster appears as a phylogenetic trait that is mainly conserved in bacilli. Molecules in Time and Space reviews the data on the formation of subcellular patterns or structures in bacteria, presents observations and hypotheses on the establishment and the maintenance of cell shape, and on the organization of genetic information in the chromosome.

Inhalt
The phylogeny of bacterial shape.- Membranes and prebiotic evolution: compartments, spatial isolation and the origin of life.- Topological domains in the cell wall of Escherichia coli.- Models for pattern formation in bacteria applied to bacterial morphogenesis.- The assembly of proteins at the cell division site.- Regulation and utilization of cell division for bacterial cell differentiation.- FtsZ folding, self-association, activation and assembly.- Sequence and structural alignments of eukaryotic and prokaryotic cytoskeletal proteins.- Bacterial morphogenes.- Genome structures, operating systems and the image of the machine.- Gene order in Prokaryotes: conservation and implications.- How similar cell division genes are located and behave in different bacteria.- The bacterial dcw gene cluster: an island in the genome?.