Monoamine Transporters

The family of monoamine transporters (MATs), composed of the dopamine transporter, serotonin transporter, and norepinephrine transporter, mediates the reuptake of dopamine, serotonin, and norepinephrine from the synapses and extra-synaptic regions, and is thus critical for regulating neurotransmission by controlling the extracellular levels of these neurotransmitters. The monoamine transporters are targets of some of the most successful psychoactive compounds, including amphetamines, cocaine, and antidepressants, among others. Monoamine Transporters will cover significant new information gained over the last decades on these important brain membrane proteins and provide a detailed overview of recent advances in our understanding of the role monoamine transporters play in both normal and disease physiology. This will include in-depth reviews of our current knowledge of their structure, function, and regulation. Translational aspects on diseases where therapeutics targeting the MATs have been successful and helped elucidate the etiology of the respective diseases will also be covered.

Presents the recent advances in our understanding of the role monoamine transporters play in normal and disease physiology Includes coverage of the new animal models for monoamine transporters Incorporates findings from recent translational perspectives

Autorentext

Ole Valente Mortensen, PhD, is Associate Professor in the Department of Pharmacology & Physiology at Drexel University College of Medicine, Philadelphia, Pennsylvania, USA. He is also Director of the Pharmacology & Physiology Graduate Program. He has a long-standing research interest in how monoamine transporters are involved in modulating monoamine signaling and associated behaviors. Dr. Mortensen obtained an MS degree from Tokyo Institute of Technology in Japan and his PhD degree from Aarhus University in Denmark. He continued his postdoctoral training under the guidance of Dr. Susan Amara at the Vollum Institute in Portland, Oregon. He was a research assistant professor at the University of Pittsburgh School of Medicine before he joined Drexel University in 2009.

Inhalt

Computational studies.- Transporter structure.- Biophysical characterization.- Oligomerization.- Electrophysiology.- Stoichiometry.- Voltammetry.- Methamphetamine and DAT.- Transporter function regulation.- Transporter phosphorylation.- Transporter trafficking regulation.- Amphetamine mediated regulation.- Atypical inhibitors.- ADHD and psychostimulants.- Neuropathic pain depression and SNRI.- Allosteric modulators.- Celegans.- KI mice.